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431 items found for " IJzerman AP"
Posts (273)
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
of PAR2 that induces unique cellular signaling, distinct from trypsin and PAR2-activating peptide (AP delayed and sustained manner compared to the rapid and transient signals induced by trypsin and PAR2-AP Interestingly, unlike PAR2-AP, GB83 and trypsin induced sustained receptor endocytosis and PAR2 colocalization
- Trevena Announce Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu ...
February 2022 Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner IV morphine, conducted in China by Nhwa Trevena is eligible to receive future success payments upon approval that China’s National Medical Products Administration (NMPA) has accepted submission of a New Drug Application of a Phase 3 bridging trial for OLINVYK (oliceridine) injection, a novel IV analgesic that has been approved
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's In vivo, we found that inhibition of GRP78-ATF6-CHOP apoptosis signaling improved ESS symptoms, and the apoptosis, and the effect depended on the interaction between GRP78 and β-arrestin2. in the pathogenesis of pSS and that β-arrestin2 encourages inflammation-induced epithelial apoptosis through GRP78-ATF6-CHOP apoptosis signaling.
Other Pages (158)
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front Our approach was confirmed by re-discovery of established cancer targets such as the LPA and mGlu receptor B J , Gorostiola González M , Wang X , van Vlijmen HWT , Jespers W , Gutiérrez-de-Terán H , Ye K , IJzerman AP , Heitman LH , van Westen GJP.
- Ep 140 with Dr Alix A J Rouault
Further, I applied to create a scientific session at the American Physiology Summit (APS) 2024 dedicated Our session was picked up by the APS.
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
Stimulation of muscarinic receptors induced strong nuclear translocation of NFAT and NFκB and activated AP