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October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system in the gut

Here, we provide guidelines and terminology for any scientists to design and report ligand bias experiments The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities analytical methods are still evolving and should benefit from and contribute to the implementation of the guidelines

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism , microbiota, and T cell-induced inflammation "Gut intraepithelial lymphocytes (IELs) are thought to Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. Such effects are mediated by the suppression of gut IEL effector functions linked to the dampening of

progression of CRC. " Authors Junwei Tang , Wen Peng , Jiangzhou Ji , Chaofan Peng , Tuo Wang , Peng Yang , Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology

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