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Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction Purpose: This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after an acute increased mRNA and protein levels of collagen I/III with higher levels of reactive oxygen species (ROS) and inflammatory Conclusion: Exendin-4 inhibits the remodeling in the remote myocardium of rats following acute MI by Β-catenin activation and nuclear translocation are associated with increased synthesis of inflammatory

Objective: The goal of this study was to determine the glucometabolic effects of acute activation of expressed by SKM at relatively high levels (β2-adrenergic receptor and CRF2 receptor) and studied the acute Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice The acute metabolic effects following agonist activation of β2-adrenergic and, potentially, CRF2 receptors The acute metabolic effects of UCN2 were not mediated by SKM Gs signaling.

chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory

< GPCR News < GPCRs in Oncology and Immunology Exacerbating effects of single-dose acute ethanol exposure Ethanol consumption has been associated with exacerbation of neurodegenerative and systemic inflammatory The goal of this study is to determine the effects of single-dose acute ethanol exposure and GPR110 activation on the neuro-inflammation mechanisms. Conclusion: Single-dose ethanol exposure exacerbated LPS-induced inflammatory responses.

discovered a novel GPCR-dependent atypical kinase activation mechanism that drives vascular edema and inflammation My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression atypical p38 signaling responses we are studying how atypical p38 controls the onset and pathogenesis of acute

GPCR News < GPCRs in Oncology and Immunology Efferocytes release extracellular vesicles to resolve inflammation clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation However, whether inflammation resolution is modulated by extracellular vesicles (EVs) and vesicular mediators signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation increase in lesional macrophage efferocytosis efficiency and a decrease in plaque necrosis and lesional inflammation