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131 items found for " Chulo Park"

Posts (80)

  • C1-inhibitor influence on platelet activation by thrombin receptors agonists

    September 2022 "Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to Here we show that C1INH affects platelet activation through PAR1 and PAR4 agonists. The platelet suspensions were exposed to PAR1 agonists SFLLRN, TFLLR and TFLLRN; PAR4 agonists AYPGKF

  • GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP

    October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by of PAR2 that induces unique cellular signaling, distinct from trypsin and PAR2-activating peptide (AP Interestingly, unlike PAR2-AP, GB83 and trypsin induced sustained receptor endocytosis and PAR2 colocalization by GB83, which may be the reason why GB83 is recognized as an antagonist of PAR2. Our results revealed that GB83 is a bona fide agonist of PAR2 that uniquely modulates PAR2-mediated cellular

  • Mark Schmeizl - Dr. GPCR Podcast

    Our guest is Mark Schmeizl!

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