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1110 items found for " Cyclin D"
Programs (8)
- Applying Pharmacology to Drug Discovery
Thank you for your interest in the Applying Pharmacology to Drug Discovery course with Dr. drug action in system-independent ways. is done. Techniques will be described to quantify drug activity in terms of affinity, efficacy, and allosteric Pharmacology is a unique discipline and is critical to drug discovery. Registrants will learn: 1.
- Dr. GPCR Ecosystem 2.0
Welcome to the new and improved Dr. GPCR Ecosystem.
- Advanced data analysis for GPCR pharmacology
Main objectives: - Learning how to perform advanced GPCR pharmacology data analysis in support of drug discovery and GPCR research, shown with GraphPad Prism - Understanding the pharmacology data analysis framework we use for GPCRs. analysis to a high level, as well as expertise that can be applied in drug discovery and target research Every participant will also have a 1:1 meeting with Dr.
Posts (592)
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
August 2022 Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, of biased compounds as both research tools and novel drugs. Although this field has exploded during the past two decades, it is only recently that highly β-arrestin biased ligands for the dopamine D1 receptor were reported. Read more at the source #DrGPCR #GPCR #IndustryNews
- Comparative study of neuropeptide signaling systems in Hemiptera
Neuropeptides and their receptors have been documented in many hemipteran insects, but the differences precursors and 48 putative neuropeptide G protein-coupled receptor (GPCR) genes were identified in D. Additionally, we discovered that the neuropeptide signaling systems of Sternorrhyncha were very different research provides more knowledge on neuropeptide systems and sets the groundwork for the creation of novel D. Read more at the source #DrGPCR #GPCR #IndustryNews
- High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
October 2022 High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened "The oncogenic G-protein-coupled receptor (GPCR) Smoothened wing imaginal disc as a model. Together, these results link the morphogenetic effects of HH to the apico-basal distribution of SMO and Read more at the source #DrGPCR #GPCR #IndustryNews
Other Pages (505)
- Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells
Oncology and Immunology Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin (ERK), AKT, and glycogen synthase kinase-3β (GSK3β), resulting in a decrease in cyclin D1 levels. Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K Souichi Yanamoto , Kotaro Tanimoto , Hitoshi Hashimoto , Yukio Ago Tags Cell cycle , Cell proliferation , Cyclin D , GPCR , VIPR2 Source < Previous Next > Classified GPCR News GPCR Weekly News GPCR Industry News GPCR
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
< GPCR News < GPCRs in Oncology and Immunology LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice Published date February 1, 2023 Abstract " LP2 is a 4, 7 D, L lanthionine-stabilized analog of angiotensin-(1- 7), with an N-terminal D-lysine, resistant to breakdown by peptidases. Subsequent studies demonstrated that LP2 at a subcutaneously injected dose as low as 0.2 µg/kg/day inhibited
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
Mice with constitutive Gαq/11 gene deletion exhibited abnormal alveolar development, with suppressed reduced TGFβ2 and elastin deposition. Cyclical mechanical stretch-induced TGFβ activation required Gαq/11 signalling and serine protease activity These data highlight a previously undescribed mechanism of cyclical stretch-induced Gαq/11-dependent Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .
Events (5)
- Development of GPCR Ligands as Therapeutic DrugsTickets: $691.88March 6, 2025Â |Â 3:00 PM
- The Practical Assessment of Signaling BiasTickets: $306.48February 20, 2025Â |Â 3:00 PM
- Practical Quantification of Allosteric ModulationTickets: $306.48April 24, 2025Â |Â 2:00 PM