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338 items found for " Duc Tin Tran"

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  • 📅 Dr. GPCR Summit 2022 is less than a month away!

    GPCR Summit 2022 is less than a month away!

  • Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...

    neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans Latrophilins in the nematode Caenorhabditis elegans can also function independently of their seven-transmembrane domain and C terminus (trans function). Here, we show that Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the This trans function is physiologically relevant in copulation behavior.

  • Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype

    August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets and also act as prototypical models for GPCR function. In a constant effort to develop drugs with less side effects, and tools to explore the ORs nature and function, various (poly)pharmacological ligand design approaches have been performed. That is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct OR subtypes), univalent heteromer-selective ligands and bitopic and allosteric ligands have been synthesized for the ORs. The scope of our review is to present the most important of the aforementioned ligands, highlight their properties and exhibit the current state-of-the-art pallet of promising drug candidates or useful molecular tools for the ORs." Read more at the source #DrGPCR #GPCR #IndustryNews

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