29 items found for " Fibrosis"
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR #IndustryNews
- A broad look into the future of systemic sclerosis
sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation, vasculopathy and fibrosis
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
Hepatic fibrosis is a critical prognostic factor in NAFLD/NASH. Therefore, a better understanding of the pathophysiology of hepatic fibrosis and the development of related However, our knowledge of how GPCRs regulate liver metabolism and fibrosis in the different cell types understanding of the role of GPCRs in hepatic stellate cells (HSCs), the primary cells that regulate liver fibrosis , may lead to the development of drugs that can improve hepatic fibrosis in NAFLD/NASH.
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
fibroblasts Published date April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic fibroblasts and the adenosine receptor antagonist, caffeine decreased Tcf21 upregulation and kidney fibrosis Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis
- Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
physiological and pathophysiological roles in renal acid-base physiology, tissue inflammation, and fibrosis