September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic In the past, treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist has been shown In this study, the expression and signaling of β2-ADR in B cells during collagen-induced arthritis (CIA Splenic B cells were isolated via magnetic-activated cell sorting (MACS). B cells increase during CIA without a change in receptor density.

Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon migration. CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging may allow cells to continuously migrate by remaining responsive to chemokines (S. migration (A.

into studies focused on obtaining detailed molecular information in the intracellular context ("in-cell ") or those focused on characterizing molecules or events at the cell surface ("on-cell"). In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution with cell surface membrane proteins such as G-protein coupled receptors (GPCRs) and receptor tyrosine We also provide a brief survey of the applicability of on-cell NMR approaches to other classes of cell

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared to controls in the impedance-based electrical wounding and migration assay. Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery

News < GPCRs in Oncology and Immunology Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy Published date September 26, 2023 Abstract "Infections are an important complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy and risks may differ between the early and late periods. Respiratory infections predominate after BCMA CAR T-cell therapy, particularly after day 100.

Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA1-selective antagonists enhanced CXCL12-induced Gαi/o signaling and cell migration in the parental Ultimately, complete inhibition of cell migration toward CXCL12 and alkyl-OMPT was only achieved in the