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Main objectives: - Learning how to perform advanced GPCR pharmacology data analysis in support of drug Pricing can change depending on the number of participants joining the team.

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Full Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Florian Seufert Structural Determinants Of GAIN ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within the GAIN We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains domain partially re-instates cleavage, while its deletion reduces cleavage in the ADGRL1 GAIN domain

< Back 22 Seeking to gain more knowledge on signaling bias?

< Back 24 Seeking to gain more knowledge on signaling bias?