that the field will have to face in the next 10 years is deciphering the physiological relevance of splice-dependent Alternative splicing events account for hundreds, if not thousands, of potentially divergent isoforms The distribution, functionality, and structure of the multiple splice isoforms that adhesion GPCRs possess aGPCR works but might also provide a guide to how pharmacological approaches will be developed, i.e., splice , for understanding tissue distribution of alternatively spliced genes.

Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified

gastrointestinal cells, we show that these isoforms emerge from distinct promoter usage and alternative splicing

training that spanned chemokine receptor conformational dynamics at the Université de Montréal, CXCR3 splice-variant Tom Sakmar's lab, where she characterized the signaling diversity of three alternative splice variants Conversation Chemokine receptor redundancy and the shift toward functional selectivity as a framework Splice Splice variants aren't just structural — they signal differently. Her Rockefeller work on the three alternative splice variants of CXCR3, initially prompted by a simple

deal of challenges given that they are highly polymorphic proteins expressed as various alternatively spliced His lab highlighted the importance of splicing events in biasing latrophilins’ regulation of cyclic AMP

Some of these studies resolved a major question regarding the signaling differences in G protein splice