inhibition of the PKA-Hippo signaling pathway Blockade of vasoactive intestinal peptide receptor 2 (VIPR2

ERK pathway Published date January 2, 2023 Abstract “ Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2 Increased VIPR2 mRNA expression and/or VIPR2 gene copy number has been documented in several cancers In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer proliferation in VIPR2-overexpressing MCF-7 and MDA-MB-231 cells. kinase (ERK), which involves a VIPR2 signaling pathway through Gs protein.