Intracellular calcium ([Ca2+]i) signaling is a critical regulator of chondrogenesis, chondrocyte differentiation Calcium (Ca2+) signaling is known to direct processes that govern chondrocyte gene expression, protein Control of chondrocyte/chondroprogenitor Ca2+ signaling has been attempted through mechanical and/or Synthetic signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection of the roles that [Ca2+]i signaling plays in chondrocyte behavior.

Ca2+ (Ca2+o ) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein-dependent signaling corresponding to heterozygous familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling In contrast, a single WT HH bundle was insufficient for maximal signaling and there was no functional Finally, we observed that the Ca2+o -stimulated CaSR operated exclusively via signaling in-trans and not via combined in-trans and in-cis signaling.

However, basic physiology of PFC astrocytes, including which neuromodulatory signals they respond to Here, we characterize divergent signaling signatures in mouse astrocytes of the PFC and primary sensory Instead, fast calcium signals in PFC astrocytes are time locked to dopamine release and are mediated Thus, we identify astrocytes as active players in dopaminergic signaling in the PFC, contributing to

and Immunology Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration Published date February 1, 2023 Abstract "C-X-C chemokine receptor Simultaneous activation of CXCR4 and HRH1 synergistically increases calcium flux in MDA-MB-231 cells Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

of the SPD model related to cell growth and migration, specifically the RTK-, integrin-, GPCR-, and calcium-signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

News < GPCRs in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling Background: G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal In contrast, CXCR4 had no impact on LPA1-mediated signaling. Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA1-selective antagonists enhanced CXCL12-induced Gαi/o signaling and cell migration in the parental