Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease The prevalence of non-alcoholic fatty liver disease (NAFLD) is Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

The present study aims to investigate the possible role of FSH excess in male bone health, by comparing

., 2017 ), including those lining bone marrow (BM) sinusoids ( Duchene et al., 2017 ).

but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled Fibrous dysplasia (FD) of the bone is characterized by fibrotic, expansile bone lesions caused by activating was hyper-activated in osteoblastic cell lineages using an engineered receptor strategy, developed a fibrotic Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor signaling

News < GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases About one-third of the commercially available drugs for various diseases target the GPCRs. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases. Sadikot , Apar K Ganti , Surinder K Batra , Maneesh Jain Tags GPCR signaling , fibroblast behavior , fibrotic

fibroblasts Published date April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G-protein coupled receptors (GPCRs) are the most druggable