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Techniques will be described to quantify drug activity in terms of affinity, efficacy, and allosteric function

The recently determined structures of B2R have provided molecular insights into the functions and regulation In this review, we summarize the structure and function of B2R in relation to drug discovery and discuss future research directions to elucidate the remaining unknown functions of B2R dimerization."

Probing GPCR and β-Arrestin conformational states: methods and implications The formation of functional Nevertheless, the diverse functionalities of various GPCRs, coupled with the fluctuating expression of In addition, the question of whether β-arrestin1 and 2 serve overlapping or distinct functions remains Knockout studies in mice suggest that β-arrestin isoforms possess some level of functional redundancy The observed variations in β-arrestin expression likely impact the composition and function of GPCR-mediated

involves deliberately altering the DNA sequence of a gene to study the resulting changes in protein function understanding of how drugs interact with different receptor regions and link these interactions to functional This technique has uncovered fundamental aspects of the G protein-coupled receptor (GPCR) function, including Targeted mutagenesis may miss broader functional regions, while random mutagenesis generates extensive play a pivotal role in addressing these obstacles, enhancing our understanding of GPCR structure and function

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Interrogating Multiscale Receptors Functions Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors (D2R) functions

Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Illuminating Functional

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function