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August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment "Background: Inflammatory microenvironment promotes odontoblastic differentiation in this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the inflammatory Methods: Microarray analysis was performed to explore the differential mRNA profiles in inflammatory

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory diseases. in immune cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory diseases."

The fact that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli such as lipopolysaccharide (LPS) and TNFα suggests that it may play a role in the development of inflammatory and fibrotic diseases. GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and function of pro-inflammatory

the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases including Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases and Keltic Pharma Therapeutics (2020) which is developing new treatments for malaria.

targeting GPCR ( Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory diseases.

Argen X and gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology. conformations, while also focusing on their therapeutic potential in oncology and transplant infectious disease