top of page
Search Results

45 items found for " neutrophils"

Posts (20)

  • Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...

    October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil Activation of Mrgpra2 by defensin triggered neutrophil release of IL-1β and CXCL2 which are vital for This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

  • GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting

    August 2022 GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order to avoid a prolonged pro-inflammatory neutrophil response, signaling chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed in neutrophils In this study, we investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

  • Platelets in the NETworks interweaving inflammation and thrombosis

    Additionally, platelet interactions with neutrophils enhance neutrophil activation and are often crucial In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs). This specific neutrophil effector function is characterized by neutrophils expelling chromatin fibres Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung and NET formation.

View All

Other Pages (25)

  • Neutrophils are itching to specialize

    < GPCR News < GPCRs in Oncology and Immunology Neutrophils are itching to specialize Published date February 13, 2024 Abstract "Neutrophils are heterogeneous, but the mechanisms underlying their ability to polarize demonstrate that the GPCR Mrgpra1 and the neuropeptide NPFF, molecules involved in pain and itch, direct neutrophil

  • A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection

    < GPCR News < GPCRs in Oncology and Immunology A GPCR-neuropeptide axis dampens hyperactive neutrophils exist as a homogeneous population is being replaced with the knowledge that neutrophils adopt different Neutrophils can have a pro-inflammatory phenotype or an anti-inflammatory state, but how these states regulator of neutrophil bactericidal functions. polarization , neutrophils .

  • Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant

    < GPCR News < GPCRs in Oncology and Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil "Microbial infection is characterized by release of multiple proinflammatory chemokines that direct neutrophils How collective function of these chemokines orchestrates neutrophil recruitment is not known. chemoattractant in mice and can recruit more neutrophils than the individual chemokines. Chemokine-mediated neutrophil recruitment is determined by Cxcr2 receptor signaling, Cxcr2 endocytosis

View All