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September 2022 Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown of YES and Src induces ERK Dasatinib-induced ERK activation was completely abolished by exposure to the FDA-approved MEK inhibitor inhibited colony formation by PDAC cells and suppessed the growth of MiaPaCa-2 cells xenografted into the flank

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< GPCR News < GPCRs in Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown of YES and Src induces ERK Dasatinib-induced ERK activation was completely abolished by exposure to the FDA-approved MEK inhibitor inhibited colony formation by PDAC cells and suppressed the growth of Mia PaCa-2 cells xenografted into the flank

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