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238 items found for "SCI-induced immunodeficiency syndrome"

Posts (179)

  • Molecular targets of psychedelic-induced plasticity

    August 2022 "Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics' potential antidepressant action." Read more at the source #DrGPCR #GPCR #IndustryNews

  • PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer

    In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation Here, we find that protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing the N-terminal portion of β-catenin suppresses the ubiquitination of β-catenin, thereby promoting PAR-induced Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally

  • Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge

    September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes." Read more at the source #DrGPCR #GPCR #IndustryNews

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Other Pages (59)

  • Ep 126 with Dr. Françoise Bachelerie

    WHIM syndrome) and in the innate control of the life cycle of papillomavirus, which are commensal inhabiting discovery that CXCL12 is the ligand for the CXCR4 receptor and can therefore prevent infection by the Human Immunodeficiency

  • LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

    < GPCR News < GPCRs in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced The addition of lysophosphatidic acid (LPA) further hindered CXCL12-induced Gαi/o recruitment to CXCR4 LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA1-selective antagonists enhanced CXCL12-induced Gαi/o signaling and cell migration in the parental

  • GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis

    Immunology GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease model to study EBV-induced

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