135 items found for "inflammation"
- Platelets in the NETworks interweaving inflammation and thrombosis
chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
September 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome The fact that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse inflammatory The mechanisms underlying their anti‐inflammatory effects were assessed using specific inhibitor, genetic
- Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
GPCR News < GPCRs in Oncology and Immunology Efferocytes release extracellular vesicles to resolve inflammation clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation However, whether inflammation resolution is modulated by extracellular vesicles (EVs) and vesicular mediators signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation increase in lesional macrophage efferocytosis efficiency and a decrease in plaque necrosis and lesional inflammation
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation A recent Inflammation Somatic Mutation (ISM) theory of cancer posits instead that tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells to engage in tissue inhalation, one of the two types of ISM-required mutations is here hypothesized to block or impede inflammation Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
and Immunology Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation suppressor gene, has received increasing attention owing to its close relationship with oxidative stress and inflammation staining, ELISA, and immunohistochemistry were used to evaluate pathological changes and the degree of inflammation Conclusions: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation