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chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory

September 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome The fact that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse inflammatory The mechanisms underlying their anti‐inflammatory effects were assessed using specific inhibitor, genetic

discovered a novel GPCR-dependent atypical kinase activation mechanism that drives vascular edema and inflammation My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

processes that control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation

research is on the mechanisms underlying biased agonism at chemokine receptors and how that contributes to inflammation