Lilly's oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial

April 14, 2025

Pfizer Provides Update on Oral GLP-1 Receptor Agonist Danuglipron

April 22, 2025

Collaboration between Nostrum Biodiscovery and Celtarys Research: a strategic alliance

GPCR Jobs

Call for GPCR Papers

Special Issue on Adhesion GPCRs

November 1, 2024

Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology

September 27, 2023

opnMe GPCR Route 66+ project

Adhesion GPCRs

March 25, 2025

Identification of a GPCR as a tip link-independent equilibrioceptor

March 26, 2025

Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development

February 18, 2025

A force-sensitive adhesion GPCR is required for equilibrioception

GPCR Activation and Signaling

April 16, 2025

Insights Into the Cellular and Molecular Mechanisms Behind the Antifibrotic Effects of Nerandomilast

April 18, 2025

Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides

April 16, 2025

Intercellular sphingolipid signaling mediates aversive learning in C. elegans

GPCR Binders, Drugs, and more

April 1, 2025

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts

April 7, 2025

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2-Adrenoceptor

April 4, 2025

Minimal Structural Variation of GPR84 Full Agonist Causes Functional Switch to Inverse Agonism

GPCRs in Cardiology, Endocrinology, and Taste

April 8, 2025

The DNA repair factor ku80 binds and activates the adhesion receptor ELTD1/ADGRL4

April 1, 2025

DRD2-Mediated AMPK Ubiquitination Regulates the Occurrence of Hepatic Steatosis

March 29, 2025

Genomic insights into ORs gene family of G protein-coupled receptors expansion driving omnivorous feeding in Spotted knifejaw (Oplegnathus punctatus)

GPCRs in Neuroscience

March 31, 2025

Neurokinin 3 receptor agonist senktide stimulates GnRH release in isolated hypogonadotropic hypogonadism mice

April 1, 2025

Evidence for Bxy-npr-21 on controlling juveniles' growth and modulating male sexual arousal: from molecules to behaviors

April 1, 2025

Characterization of Anthozoan-Specific Opsins from a Reef-Building Coral, Acropora tenuis, as Gq-Coupled Opsins

GPCRs in Oncology and Immunology

April 10, 2025

SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer

April 7, 2025

G-protein coupled receptors in metabolic reprogramming and cancer

April 4, 2025

Unveiling the Role of DPYS: A New Prognostic Biomarker in Sarcoma

Methods & Updates in GPCR Research

April 18, 2025

Structural Systems Biology Toolkit (SSBtoolkit): From Molecular Structure to Subcellular Signaling Pathways

April 7, 2025

Topology-Driven Negative Sampling Enhances Generalizability in Protein-Protein Interaction Prediction

April 7, 2025

A new approach to psoriasis therapy: photoswitchable A3 adenosine receptor activation

Reviews, GPCRs, and more

April 18, 2025

Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research

April 9, 2025

Where are we now? Biased signalling of Class B G protein-coupled receptor-targeted therapeutics

April 1, 2025

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail

Structural and molecular insights into GPCR function

April 17, 2025

Structural dynamics of olfactory receptors: implications for odorant binding and activation mechanisms

April 15, 2025

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

April 3, 2025

Proton perception and activation of a proton-sensing GPCR

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