Bryan Roth joins the Dr. GPCR community live this week to examine what standard models don't account for — what happens when GPCR selectivity is encoded at the receptor–transducer interface rather than the receptor alone. This is one of 12+ live Masterclasses planned for 2026, all included in Premium. Also this week: Terry Hébert previews his April 16 session on iPSC-derived models, and a new podcast episode with Joseph Kim on GPCR structural biology and drug discovery.

GPCR internalization does not end signaling — it redirects it. This article explores the assays, beta-arrestin gating mechanisms, and recycling-versus-degradation frameworks that determine receptor fate inside the cell.