Your One-Stop-Shop for GPCR Drug Discovery and Development
Researchers developing GPCR-targeted therapeutics need a reliable, comprehensive partner that spans discovery, optimization, and regulatory submission.
Eurofins DiscoverX leads GPCR research innovation with 25+ years of expertise and provides you with cell-based assay solutions for basic research through therapeutic discovery and development. The assays are validated and accepted by industry and the scientific community, with thousands of peer-reviewed publications and billions of data points screened. These industry-standard assays, designed for regulatory submissions, are backed by partnerships with leading pharma companies worldwide.
GPCR Product Solutions
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Determine rank-order hits, evaluate ligand bias or allostery, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors, and more
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Perform target identification and validation, high-throughput screening (HTS), lead optimization, safety assessment, and regulatory potency testing for commercial release
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Access a complete toolkit for GPCR solutions: cell line assay kits, cell lines, ready-to-use assays, detection kits, custom products, and more
Comprehensive Coverage
>1500 Human GPCRs products, including:
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90% Target coverage
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Orphan receptors
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Ortholog variants
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Multiple cell line backgrounds
Multiple Mechanisms of Actions (MOA)
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cAMP accumulation
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β-Arrestin recruitment
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Receptor internalization
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Ligand binding
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Calcium flux
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Pharmaco Chaperone discovery
Numerous Product Types
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Cell line assay kits
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Cell lines
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Qualified bioassays
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eXpress assay kits
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Membrane preps
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Detection kits
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Custom products
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Services
Access Product Solutions and Key Resources
GPCR Functional Cell-Based Assays - Assessing Biased Signaling of Agonist
The Human GPCRome
Flexible Formats for Every Research Need
Eurofins DiscoverX understands that different research stages require different tools. This comprehensive portfolio offers multiple product formats to match your exact needs, whether you're conducting exploratory screens or regulatory-compliant potency testing.
Assay Principle of Eurofins DiscoverX Cell-based Assays
Whether you are developing small-molecule or biologic therapeutic drugs, Eurofins DiscoverX provides you with a variety of drug discovery and development products with multiple assay types and applications to meet your specific GPCR research needs.
Supporting Obesity and Diabetes Research
Eurofins DiscoverX supports the ongoing obesity/diabetes revolution with the most comprehensive, validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors, and more.
Browse products related to your obesity/diabetes target of interest:
Representative Data: GLP-1R Multi-MOA Profiling
Eurofins DiscoverX's GLP-1 receptor (GLP-1R) assay portfolio illustrates a comprehensive approach to obesity research, with complete MOA coverage for a single target: GLP-1. These assays enable complete pharmacological profiling across cAMP, β-arrestin, and internalization.
GLP-1R representative assay results (dose-response curves) for exendin-4, tirzepatide, and retatrutide.
A. cAMP dose–response;
B. β-arrestin recruitment showing ligand bias; and
C. internalization profiles distinguishing highly versus weakly internalizing agonists.
Together, these datasets exemplify the depth of pharmacological insight enabled by Eurofins DiscoverX platforms. This multi-dimensional characterization extends across our full obesity and diabetes product portfolio, including GIPR, GCGR, AMY receptors, MC4R, and beyond.
Beyond Eurofins DiscoverX Products: The Full Power of Eurofins Discovery
Eurofins DiscoverX cell lines, assays, kits, and custom product solutions represent the foundation of tools for GPCR research and drug discovery and development. When these product solutions are combined with Calixar GPCR membrane proteins and Eurofins Discovery GPCR services, the benefits from integration provide the most comprehensive GPCR research and drug discovery platform spanning the entire discovery and development continuum.
Eurofins Discovery GPCR services offer hundreds of binding and functional assays, available individually or in panels. These assays use the same platform as the Eurofins DiscoverX assays and beyond.
Calixar GPCR membrane proteins, as a service, provides a wide array of GPCRs from various species, purified to the highest standards to ensure purity, integrity, and biological activity. These GPCRs are excellent for use in functional, structural, or identification assays, as they are strictly identical to the ones in membranes.
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Let Us Help You Get Started!
Contact a Eurofins DiscoverX Specialist or visit GPCR Product Solutions for more information on GPCR cell-based solutions for basic research, discovery, and therapeutic development.