This comprehensive course is designed to provide an in-depth exploration of key concepts in pharmacology, offering a nuanced understanding of drug interactions and mechanisms of action. The curriculum is divided into four modules, each focusing on essential aspects of pharmacological principles. Whether you are a healthcare professional, researcher, or student in the life sciences, this course will enhance your knowledge and critical thinking skills in the field of pharmacology.

GPCR Ecosystem.

GPCR Ecosystem.

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because Using the parathyroid hormone type 1 receptor (PTHR) as a prototypic class B GPCR target, and a combination of molecular dynamics simulations and elastic network model-based methods, we demonstrate that PTHR druggability This study provides a computational pipeline to detect precise druggable sites and identify allosteric modulators of PTHR signaling that could be extended to GPCRs to expedite discoveries of small molecules

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations GPCR targeting drugs: orthosteric vs allosteric sites Most of the drugs targeting GPCRs bind to the orthosteric GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior Agonist binding to GPCRs doesn't always trigger all associated events sequentially. selectively activate specific cellular outcomes linked to that GPCR.

GPCR Podcast << Back to podcast list Dr. Arthur Christopoulos About Dr. I aim to discover new therapeutic approaches, and druggable molecules or refine canonical drug targets PhD studies in Martin Lohse lab at the Max Delbrueck Center in Berlin, I consolidated my knowledge of GPCRs cell-based experiments to understand the binding, activation, and signaling of therapeutically relevant GPCRs GPCR Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast Episode

GPCR Ecosystem We bring the GPCR community to fuel GPCR drug discovery one receptor at a time. The goal is to increase understanding of GPCR function and discover better drugs together. About Us: About Us Founded in 2020, we decided to bring together the GPCR community and break down any The goal is to better understand and exploit the druggability of GPCRs, together. To join the community you must be related to the GPCR field. Once in the Dr.

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites overview of an open-source resource for simultaneous interrogation of bioactive molecules across the druggable News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs