Your One-Stop-Shop for End-to-End GPCR Drug Discovery Services
As a trusted discovery partner, Eurofins Discovery transforms complex GPCR pharmacology intoclear, actionable insights through unmatched assay breadth, scientific expertise, and end-to-endcapabilities spanning target validation to candidate advancement. Backed by more than 30 years of GPCR experience, including 20+ years of successful Integrated Drug Discovery (IDD) expertise, and a portfolio of over 2,750 assays, covering one of the broadest ranges of GPCR targets in the industry, we provide the flexibility and expertise needed at every stage of discovery.
Beyond screening, our capabilities include custom assay development, deorphanization, biophysical characterization, translational models, and advanced pharmacology support. Combined with high-throughput execution and rapid turnaround times, we help generate the biologically relevant insights needed to reduce risk and advance the right candidates forward.
GPCR Screening Services
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Characterize and rank order compounds
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Assess potency, efficacy, selectivity, and safety
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Evaluate biased signaling and allosteric modulation
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Investigate species-specific pharmacology
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Deorphanize receptors and identify ligands
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Advance candidates with translationally relevant data
Flexible Study Formats
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Screening campaigns
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Mechanistic pharmacology studies
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Custom assay solutions
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Translational & advanced cell models
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Cell-based and biochemical assays
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In vitro efficacy studies
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Client-tailored project design
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Rapid turnaround execution
Functional Pharmacology & Binding Expertise
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> 2700 Human GPCR assays including
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cAMP, β-Arrestin, calcium flux, receptor internalization
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Radioligand binding, affinity determination, kinetic characterization
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Biased signaling and allosteric modulation
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Ortholog and species variant profiling
Integrated Discovery Capabilities
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Target identification & validation
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Protein science
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High-throughput screening (HTS)
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Hit confirmation & profiling
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Lead optimization support
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Custom assay development
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Deorphanization services
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Safety pharmacology
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Regulatory potency testing
Pharmacology endpoints
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Detailed characterization of GPCR activity and function
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Capabilities span the key endpoints that describe how a receptor behaves
Key areas
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Services across the discovery continuum
Binding & Functional GPCR Assays
The industry's most extensive collection of validated assays, available individually or in panels.
Biophysics
Biophysical characterization for mechanistic, structure-informed insight.
Custom Assays & Deorphanization
Custom assay development and deorphanization for challenging or novel targets.
Integrated Drug Discovery
End-to-end programs from target validation through candidate advancement.
Protein Production
GPCR protein production to support downstream functional and structural work.
Advanced Pharmacology & Translational Models