First AMA of 2026: GPCR Pharmacology, Biased Signaling & Mechanistic Clarity
- Terry's Desk
- 12 hours ago
- 2 min read
2026 GPCR Pharmacology AMA: Receptor Theory, Biased Signaling & Assay Interpretation
The first GPCR Pharmacology AMA of 2026 at Terry’s Corner will take place on:
Thursday, February 26 at 1 PM EST
Dr. Kenakin will address receptor theory, assay interpretation, biased signaling, and practical drug discovery challenges — driven by questions from the community.
These sessions focus on real scientific uncertainty, not rehearsed presentations.
Terry’s Corner Expands to YouTube
Terry’s Corner is now on YouTube.
Three videos are already live, and the channel will expand regularly.
The objective is straightforward:
Make mechanistic pharmacology easier to access, revisit, and apply across research teams.
Short conceptual breakdowns
Focused receptor theory discussions
Clear explanations reinforcing disciplined interpretation
As the archive grows, it becomes a searchable extension of Terry’s teaching — designed for repeated exposure rather than one-time viewing.
Subscribe to stay current as new videos are released:
New White Paper on GPCR Biased Signaling
Terry Kenakin, Ph.D., Professor of Pharmacology at the University of North Carolina School of Medicine, has authored a new white paper in collaboration with Eurofins DiscoverX: Assess GPCR Biased Signaling of Agonists Using Functional Cell-Based Assays
The paper explores:
Detection and quantification of signaling bias
Influence of biased signaling on therapeutic profiles
Application of quantitative tools such as transduction coefficients(log(τ/KA) or log(max/EC50))
Systematic comparison of biased agonists using modern functional assays
For scientists working in GPCR programs, this connects functional assay data directly to translational decision-making — moving beyond descriptive bias claims toward quantitative rigor.
Why Terry’s Pharmacology Corner
Mechanistic understanding evolves.
What appears settled under one experimental condition may require refinement under another. What seems definitive during early screening can shift as assay systems, receptor expression levels, or kinetics change.
Pharmacology does not drift because data are missing. It drifts when interpretation becomes casual.
Terry’s Pharmacology Corner provides a structured environment to maintain interpretive discipline:
Weekly advanced pharmacology lectures
Monthly live AMAs for real-time scientific discussion
A continually expanding on-demand archive
Sustained exposure to quantitative receptor theory and mechanistic reasoning
The value lies not in a single explanation, but in preserving rigor as programs mature.
Forty years of pharmacological expertise — organized into a year-round framework for serious GPCR scientists.
Stay in the Know
If you want updates on future AMAs, new YouTube releases, white papers, and ongoing pharmacology insights, join Terry Kenakin’s Brief.
Concise. Focused. Mechanistic.
Continue the Work
Live sessions are one layer.
Sustained exposure is where judgment sharpens.
If you want structured, year-round access to Terry’s full library — including advanced
lectures, archived AMAs, and quantitative pharmacology deep dives:
Strengthen Your Mechanistic Thinking
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