Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
GPCR News
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Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
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Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
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Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
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High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
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Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
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Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
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Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures
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Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
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Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...
- Oct 1, 2022
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Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
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Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
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Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
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Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
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Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
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Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
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Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
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Endosomal parathyroid hormone receptor signaling
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Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
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Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
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Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
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Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
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GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
- Oct 1, 2022
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Endogenous ligand recognition and structural transition of a human PTH receptor