Insights That Move the GPCR Field Forward

Dr. Maria Majellaro shares the pivotal moments that shaped her career, from chemistry tests to launching a biotech company changing GPCR research.

Understanding receptor-ligand interaction is key in drug discovery and biomedical research. Radioligands have been used to study GPCRs...

How Maria Majellaro transitioned from medicinal chemist to biotech CSO, and how Celtarys is now advancing GPCR research tools with Dr. GPCR.

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr. Maria Majellaro, highlighting their fluorescent ligand tools for live-cell GPCR assays.   After 40+ years and 250 publications, Dr. Terry Kenakin is launching a new learning space with video courses, AMAs, and practical insights . Get a sneak peek  and sign up for The Kenakin Brief—his free weekly newslette r.   On the industry side, Novo N

Today’s GPCR researchers want multiplexing, miniaturization, and scale. Here’s the toolkit delivering just that and why it matters now.

Celtarys Research Joins Dr. GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. This partnership aims to bring advanced chemical probe strategies to the forefront. The goal is to accelerate receptor-targeted discovery. They will showcase innovative conjugation methods. These methods will provide scientists with direct access to emerging tools and insights. Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Publi

Dr. Sakmar reveals how activating GPCR autoantibodies could be driving disease—and how new tools make them detectable.

Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand technology and accelerate the development of GPCR-targeted therapeutics.

1.       Introduction Dopamine receptors are G-protein-coupled receptors (GPCRs), which have 5 subtypes -D1-5. The dysfunction of these...

Hello Dr.GPCR readers! This is Lucía from the Celtarys Research chemistry team.  For our very first post in this ecosystem, we wanted to...

How one lab’s 30-year GPCR journey became a global resource. Tools, tech, and team science driving GPCR-RAMP discovery.

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.   Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years of GPCR-RAMP discovery. Additionally, new studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid probe tracks early

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. GPCR updates: sharpen your skills with our new on-demand course, Techniques for Effective Lead Optimization with Dr. Terry Kenakin, and catch up on cutting-edge insights through our full library of symposia recordings, now available with your Premium Membership.   We’re also spotlighting breakthroughs that challenge dogma and deepen our view of receptor dynamics, from the surprising discovery that β-a

Ben Clements reflects on pacing, imposter syndrome, and a 10x opioid breakthrough, all powered by curiosity and timing.

Ben Clements shares why fun, mentorship, and community are just as critical as experimental design in GPCR research labs.

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. GPCR Store, and a spotlight on the cryo-EM structure of the sweet taste receptor.   We’re also tracking biased signaling in Class B GPCRs, the membrane-driven modulation of mGluR2, and a big headline, Novo Nordisk’s $2.2B deal with Septerna to develop GPCR-targeted obesity therapeutics.  Scroll down for the science, the strategy, and the sweet stuff 🍬

Hello GPCR Colleagues and Collaborators, We’re diving into May with serious momentum. This week brings sharp new insights into how minor changes in ligand structure can flip GPCR function, how ACKR3 modulates cardiac lymphatic repair, and how β-arrestins decode GPCR phosphorylation barcodes. Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. GPCR Updates   We want your feedback - Help shape the future of Dr. GPCR.   Your voice matters. Every ins

A bold new approach to opioid therapy: Ben Clements discusses GPCR-based allosteric modulators and their promise in treating chronic pain without the side effects.

Ho, ho, ho, GPCR elves! As the year wraps up, we're thrilled to present the final edition of the GPCR Weekly Newsletter for 2024! As researchers, we all understand the importance of data in driving meaningful discoveries  and advancing our experiments.   At Dr. GPCR, we believe the same principle applies to building a better experience  for our online community.   We’d love to hear your thoughts on our website and its features  so that we can continue to support your work and

Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! We've got an early holiday treat for you: The University CheatSheet ! Dive into our courses, talks, poster presentations, and more! This Week’s Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Society Honorary Fellowship! 🎉 Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR

Grab your flux capacitors, GPCR time travelers! We're zooming back to the future of GPCR discoveries. Buckle up as we time-hop through this week's GPCR escapade! This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Gorvin , Alexander S Hauser Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , G

Greetings, GPCR Colleague! Prepare to be amazed! Shocking GPCR revelations await you. Explore the newest breakthroughs and thrilling research findings in this week's update! This Week’s Highlights: Celebrating Excellence:   Patrick Sexton  and Arthur Christopoulos  Named Among Top 1% of Scientists in Pharmacology and Toxicology for 2024 ! High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  E