GPCR NewsOct 1, 20221 minGPCRs in NeuroscienceG protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways,...
GPCR NewsSep 1, 20221 minGPCR Activation and SignalingGPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization, internalization, and...
GPCR NewsAug 1, 20221 minReviews, GPCRs, and moreStructural basis of GPCR coupling to distinct signal transducers: implications for biased signalingAugust 2022 "Three classes of G-protein-coupled receptor (GPCR) partners - G proteins, GPCR kinases, and arrestins - preferentially bind...
GPCR NewsDec 11, 20211 minGPCR Activation and SignalingA Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase FgrArrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the...