Insights That Move the GPCR Field Forward

Integrated GPCR drug discovery demands more than isolated experiments. It requires alignment across chemistry, modeling, pharmacology, and translational strategy. This week, we introduce the newly structured Dr. GPCR University — ten reformatted masterclasses now fully integrated into Premium — and what that means for discovery teams.

The difference between orthosteric vs. allosteric mechanisms isn’t just academic — an orthosteric antagonist can hijack receptor physiology, while an allosteric modulator works with the system. That choice determines whether you risk over- or under-dosing, miss safety windows, or miss therapeutic breakthroughs.

Turn assay snapshots into predictions. Models separate orthosteric vs allosteric mechanisms and guide experiments for faster decisions in Terry’s Corner.