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The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
GPCR Articles
Kiyan Afzali
Mar 10
11 min read
Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
GPCR Papers
GPCR News
Oct 1, 2022
1 min read
Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
GPCR Papers
GPCR News
Oct 1, 2022
1 min read
Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
GPCR Papers
GPCR News
Oct 1, 2022
2 min read
GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
GPCR Papers
GPCR News
Oct 1, 2022
1 min read
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
GPCR Papers
GPCR News
Oct 1, 2022
1 min read
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
GPCR Papers
GPCR News
Oct 1, 2022
1 min read
Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
Multifunctional role of GPCR signaling in epithelial tube formation
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting
GPCR Papers
GPCR News
Aug 1, 2022
1 min read
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