Reflections on My PhD Journey: Lessons Learned
The journey of a PhD is a unique blend of intellectual discovery, resilience, and personal growth. My experience has been no different,...
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Cam Sinh Lu
Nov 124 min read
Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
Deep mutational scanning (DMS) is a powerful method for studying the functional consequences of various genetic variants within a...
820
John Teye Azietaku
Oct 293 min read
Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling
G protein-coupled receptors (GPCRs) are membrane-bound proteins that sense external stimuli and relay signals inside the cell, resulting...
890
Monserrat Avila-Zozaya
Oct 222 min read
Profiling Immune Cell and Platelet Transcriptomes
G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological processes and serving...
450
Cam Sinh Lu
Oct 83 min read
Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case study is essential to deepen...
1170
Ya-Tzu Li
Oct 12 min read
AlphaFold’s Breakthrough in GPCR Research: Revolutionizing Discovery, Yet Awaiting Experimental Proof
Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR) structures,...
1100
John Teye Azietaku
Sep 234 min read
Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
Biased agonism is a phenomenon where different ligands acting on the same receptor trigger distinct signaling pathways, leading to varied...
1830
Monserrat Avila-Zozaya
Sep 102 min read
APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
Significant advancements in the cellular biology of G protein-coupled receptors (GPCRs) about a novel biosensor shed light on the...
740
Cam Sinh Lu
Sep 34 min read
Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to dramatic, either locally or...
1360
Ya-Tzu Li
Jun 253 min read
Do You Believe AI Could Accelerate Drug Discovery?
The advent of AlphaFold2 (AF2) has brought AI applications in drug development to unprecedented heights. Its groundbreaking ability to...
880
John Teye Azietaku
Jun 183 min read
Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting external stimuli into...
1590
Monserrat Avila-Zozaya
Jun 113 min read
Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors (GPCRs) and receptor...
1330
Inês Pinheiro
Jun 42 min read
Canonical chemokine receptors as scavenging “decoys”
The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation, as well as to play vital...
790
Cam Sinh Lu
May 283 min read
Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
“The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.” Sir William Osler Scientists have...
1360
Ya-Tzu Li
May 213 min read
Dynamic GPCR activation revealed through time-resolved Cryo-EM
Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the external environment. These...
230
John Teye Azietaku
May 144 min read
Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular signals, including hormones,...
2500
Monserrat Avila-Zozaya
Apr 164 min read
From DNA day to GPCR genomics
April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure in 1953 and the completion of...
570
Inês Pinheiro
Apr 25 min read
GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations that recruit and ultimately...
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Monserrat Avila-Zozaya
Mar 55 min read
An overview of the compartmentalized GPCR Signaling: Relevance and Implications
When it comes to signal transduction, cellular context matters. The cellular context is crucial for understanding the diverse signaling...
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Inês Pinheiro
Jan 94 min read
Chemokine receptor-targeted drug discovery: progress and challenges
The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious diseases (Proudfoot 2002), and in...
2030
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