Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR) for 19F-NMR...
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GPCR News
- Oct 1, 2022
- 1 min
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
October 2022 β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells...
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GPCR News
- Oct 1, 2022
- 1 min
Single-molecule counting applied to the study of GPCR oligomerization
October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular abundance and stoichiometry of...
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GPCR News
- Oct 1, 2022
- 1 min
Design and validation of recombinant protein standards for quantitative Western blot analysis of...
October 2022 Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor...
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GPCR News
- Oct 1, 2022
- 1 min
Label-free LC-MS based assay to characterize small molecule compound binding to cells
October 2022 "Study of small molecule binding to live cells provides important information on the characterization of ligands...
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GPCR News
- Oct 1, 2022
- 1 min
Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
October 2022 Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes...
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GPCR News
- Oct 1, 2022
- 1 min
Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting...
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GPCR News
- Aug 1, 2022
- 1 min
Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
August 2022 Production of human A 2A AR in lipid nanodiscs for 19 F-NMR and single-molecule fluorescence spectroscopy "We describe...
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GPCR News
- Aug 1, 2022
- 1 min
In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells and tissues...
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GPCR News
- Aug 1, 2022
- 1 min
Luciferase-based GloSensorâ„¢ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensorâ„¢ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G...
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GPCR News
- Aug 1, 2022
- 1 min
A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living...
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GPCR News
- Dec 16, 2021
- 1 min
Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
The physiological mechanisms driving synapse formation are elusive. Although numerous signals are known to regulate synapses, it remains...
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GPCR News
- Dec 2, 2021
- 1 min
HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide...
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GPCR News
- Dec 1, 2021
- 1 min
On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
Nuclear magnetic resonance (NMR) spectroscopy allows the determination of atomic-level information on intermolecular interactions,...
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