Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
GPCR News
- Nov 1, 2022
- 1 min
Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
- Oct 1, 2022
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Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
- Oct 1, 2022
- 1 min
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
- Oct 1, 2022
- 1 min
Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
- Oct 1, 2022
- 1 min
Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
- Aug 1, 2022
- 1 min
In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
- Aug 1, 2022
- 1 min
Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
- Aug 1, 2022
- 1 min
Exploring pharmacological inhibition of G q/11 as an analgesic strategy
- Aug 1, 2022
- 1 min
Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
- Aug 1, 2022
- 1 min
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
- Aug 1, 2022
- 1 min
Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
- Aug 1, 2022
- 1 min
Effects of Small Molecule Ligands on ACKR3 Receptors
- Aug 1, 2022
- 1 min
A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
- Aug 1, 2022
- 1 min
Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
- Aug 1, 2022
- 1 min
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
- Dec 23, 2021
- 1 min
Precise druggability of the PTH type 1 receptor
- Dec 22, 2021
- 1 min
A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
- Dec 17, 2021
- 1 min
Applications of Cryo-EM in small molecule and biologics drug design
- Dec 12, 2021
- 1 min
Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs