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Luisa Salter-Cid, Dr. Omar Nadeem and Dr.

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of

In this session, you’ll gain: ✅ A deeper understanding of how every ligand alters receptor conformation—and why this can’t be ignored  ✅ Practical examples of how probe dependence  alters efficacy, selectivity These changes can alter how the receptor talks to G proteins, arrestins, or other receptors. how cryptic binding pockets —sites that only exist briefly in certain receptor states—can drastically alter In this lecture, Kenakin lays out why no ligand binds without altering receptor conformation , and how

Alexander Hauser , and Luise Wagner .