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My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites During my post-doctoral research, I was part of a study that identified the receptors of a novel human serve as targets for more than one-third of all prescribed drugs currently used in the treatment of human

the innate control of the life cycle of papillomavirus, which are commensal inhabiting the healthy human discovery that CXCL12 is the ligand for the CXCR4 receptor and can therefore prevent infection by the Human

profile, we have developed antibody-drug conjugates (ADCs) targeting CD97, by screening a synthetic human We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types We also found significantly lower LD50 values when treating human GBM cells with the ADC (0.6788 nM), studies oncogenesis in glioblastoma, the most common brain malignancy, and chromatin organization in human

Eddy began learning and investigating human GPCRs while training in the laboratories of Professors Raymond

form trusting partnerships, grow, and thrive together to accelerate GPCR drug discovery and improve human

biosensors directed at AGPCR signaling and function The NTF Release Sensor Approach for Drug Discovery for Human Approach (MS-BRET) Ana Lilia Moreno Salinas The NTF Release Sensor Approach for Drug Discovery for Human It was then adapted for the human aGPCRs CD97/ADGRE5 and Latrophilin/ADGRL3 and tested in HEK293T cells identification of drugs targeting the unique aGPCR receptor family and customize the method for disease-relevant human

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia resulted in her

This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human

Department of Drug Design and Pharmacology in Copenhagen, he worked on novel analytical methods to identify human

Professor in the Departments of Pharmacological Sciences, Neuroscience, and Artificial Intelligence and Human

orthosteric and allosteric interactions, and still looking for some bias ... anywhere ... these days human

extends to the development of novel screening approaches to identify pharmacological modulators of human

has worked on building large-scale ways of empirically exploring questions in protein biochemistry, human

many physiological processes, making them a focal point of scientific research with implications for human

structural biology, and pharmacology can provide new opportunities to improve our understanding of human

Since my undergraduate studies, I have been engaged in researching molecular mechanisms that govern human

to find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies of human

families of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human

A second area of interest has been the elucidation of the molecular basis for a rare autosomal human

be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

of GPCR biology, acquired critical expertise, and rigorous approaches to examine PAR1 function using human

be the Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) -Human

genetic risk factors implicated in schizophrenia by large whole-genome association studies (GWAS) in humans

Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb

March 26, 2025 Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human Binders, Drugs, and more April 1, 2025 Identification of anti-resorptive GPCRs by high-content imaging in human

Contribution: From Mechanistic Insight to Human-Centered Impact Catherine’s research now extends to real-world Looking ahead, Catherine is planning a sabbatical to work on human studies of polysubstance abuse, with