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Posts (18)
- GPCR Allosteric Modulation: Why Allostery is the Engine of Drug Discovery
But that model is no longer sufficient. Cryptic Sites, Longer Onset: Why Some Drugs Work Differently in Cells Than in Assays One of the most You’ll walk away with tools to: Interpret probe-dependent effects Model and anticipate longer equilibration
- Why Intracellular Drugs May Hold the Key to GPCR Therapeutics
You get longer activity with shorter exposure—a dream scenario for drug designers. The slow-offset compound stays on target longer, maintains therapeutic effect as concentrations drop, Persistent binding isn’t just about longer half-lives—it’s about smarter pharmacology.
- Decoding Olfactory GPCRs: How AlphaFold and AI Are Changing the Game
This case study highlights why computational chemistry is no longer a side tool—it’s a driver of discovery
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