This comprehensive course is designed to provide an in-depth exploration of key concepts in pharmacology, offering a nuanced understanding of drug interactions and mechanisms of action. The curriculum is divided into four modules, each focusing on essential aspects of pharmacological principles. Whether you are a healthcare professional, researcher, or student in the life sciences, this course will enhance your knowledge and critical thinking skills in the field of pharmacology.

GPCR Ecosystem.

GPCR Ecosystem.

G protein-coupled receptors (GPCRs) are among the most promising drug targets. Specifically controlling the activity of GPCR dimers with ligands is a good approach to clarify their This region corresponds to the sodium ion binding site in class A GPCRs that controls the basal state reveal the possibility of developing allosteric compounds able to specifically modulate the activity of GPCR

A G-protein coupled receptors (GPCRs) through a conserved binding site, not present in class B GPCRs For class B GPCRs, previous molecular dynamics (MD) simulation studies have shown PI(4,5)P2 interacting Interestingly, we find that in contrast to class A GPCRs, PI(4,5)P2 appear to stabilize the inactive conformation of GCGR through a binding site conserved across class B GPCRs but absent in class A GPCRs This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs."

sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs The TAS1R2 and TAS1R3 subunits are members of a small family of class C GPCRs whose members share the Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR VideoCast << Back to VideoCast list Dr. Qing Fan About this episode Dr. Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit GPCR Ecosystem Listen and subscribe where you get your podcasts Tags ​ << Previous VideoCast Episode

GPCR VideoCast << Back to VideoCast list Dr. Benjamin Myers About Dr. Ben’s research focuses on Smoothened and other class F GPCRs which play essential roles in embryonic These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and for GPCRs to control intracellular kinases. More recently, Ben’s lab has begun studying GPCR signaling pathways that operate within the primary cilium

GPCR at the Great Lakes GPCR Retreat : We'd like to thank the organizers for a great meeting! GPCR has affected you and the field today . GPCR News 1. function Structural perspective of class B1 GPCR signaling. Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective. Optical control of Class A G protein-coupled receptors with photoswitchable ligands.