top of page
Search Results

298 items found for " Specialized pro-resolving mediators"

Posts (165)

  • High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...

    September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways while a new estrogen receptor, namely G protein-coupled estrogen receptor (GPER), is demonstrated to mediate At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

  • Molecular insights into psychedelic drug action

    August 2022 "A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a "Breakthrough Therapy" for treatment-resistant depression, a new path has been forged for the conveyance of psychedelics to the clinic. Essential to the further development of such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular level. Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic mechanisms." Read more at the source #DrGPCR #GPCR #IndustryNews

  • GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...

    September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization The spatial pattern of GPCR phosphorylation is predicted to trigger these discrete GRK and arrestin-mediated carboxyl-terminal tail (C-tail), but not proximal, phosphorylation of the chemokine receptor CXCR4 specifies We demonstrate by pharmacologic inhibition of GRK2/3-mediated phosphorylation of the chemokine receptor In conclusion, this study provides evidence that distal C-tail phosphorylation sites specify GRK-βarrestin-mediated

View All

Other Pages (133)

View All