September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism , microbiota, and T cell-induced inflammation "Gut intraepithelial lymphocytes (IELs) are thought to Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. activation in gut IELs to modulation of microbiota composition and control of intestinal and systemic

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system in the gut

GPCR drug discovery via multitask learning GPCRs in Cardiology, Endocrinology, and Taste The Role of Gut Microbiota and Associated Compounds in Cardiovascular Health and its Therapeutic Implications The perspective

Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota the Immune System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases, most of which are immune based, in tissues remote from the gut." Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

Indeed, gut microbiota dysbiosis and metabolomic profile alterations, are hallmarks of IBD. The aim of this study was to characterize the axis microbiota-metabolite-GPCR in intestinal surgical Results showed that UC patients had a lower microbiota richness and bacterial load, with a higher proportion Barrachina, Jesús Cosín-Roger Tags GPR109A , IBD , Metabolite-sensing GPCRs , Metabolomic alterations , Microbiota

intestinal dendritic cells Published date October 29, 2024 Abstract "The intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules for gut immune cells. G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut Here, we show that GPR31, which is activated by the gut bacterial metabolite pyruvate, is specifically Using human induced pluripotent stem cell-derived cDC1s and a monolayer human gut organoid coculture