Whether you are a healthcare professional, researcher, or student in the life sciences, this course will

October 2022 Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric tissue response to a given dose of the hormone or its antagonist depends on receptors that engage the ligand Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution. , X-ray structures of both AngII receptors (AT1 and AT2 receptors) bound to peptide and non-peptide ligands Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus

Intriguingly, the two ligands have distinct signaling and physiological properties: PTH evokes prolonged The distinct molecular actions are ascribed to the differences in ligand recognition and dissociation A comparison of the PTH-bound and PTHrP-bound structures reveals distinct ligand-receptor interactions underlying the ligand affinity and selectivity. dissociation from the receptor and shed light on the distinct durations of signaling induced by PTH

October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz Previous assays verified that a typical G protein-coupled receptor, β-adrenergic-like octopamine receptor

Kong , Xu Wang , Ya-Kun Gao , Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular

speakers: Alexei Sirbu (Max Delbrück Center); Polina Isaikina ( Paul Scherrer Institut PSI); Jianming Han If you’d like to present your work during networking time on September 22nd, please fill out this form If you’d like to register your lab/team or live in a developing country , please reach out, and we will If your organization would like to become a partner, contact us here .

We detected the expression of GPR37 in NSCLC tissues and cell lines. Authors Han Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei