G protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial smooth muscle smooth muscle cell (VSMC) proliferation, contributing to the development of atherosclerotic plaques, re-stenosis lesions and vascular remodelling. Using two indices of cell growth, we show that PI3K inhibition and depletion of GRK2 expression produced ability to promote efficient prolonged PI3K-Akt signalling, and thus relieve the GSK3-mediated block on cell

August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs).

One suggested theory is that cannabinoids regulate a variety of physiological processes within the cells Murine L6 skeletal muscle cells were used in order to clarify additional possible molecular signaling Skeletal muscle cells have often been used; it is well-documented that they express cannabinoid receptors In the current work, it is demonstrated that skeletal muscle cells exhibit functional expression of CB1 Thus, in skeletal muscle cells, a possible physiological expression of CB1 receptors was identified.

< GPCR News < GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic heterogeneity and vascular However, its role in normal and tumor vascular remodeling is controversial. The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon Become a Contributor

protein-coupled receptor (GPCR) genes Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells Lipolysis drives expression of the constitutively active receptor GPR3 to induce pediatric H3 K27M-mutant diffuse midline glioma and examination of its role in diffuse midline glioma cell muscle cells 1.5 GPCRs in Neuroscience A photoswitchable GPCR-based opsin for presynaptic inhibition in GPCR Research Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable

Muscle Cells. Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia . cell type-specific functions. Cotranslational assembly of membrane protein/nanoparticles in cell-free systems .