📰 GPCR Weekly News, May 8 to 14, 2023

Hi GPCR lovers! Stay tuned for the latest buzz on GPCRs. This week's GPCR papers feature publications from Drs. Vladimir Katanaev and Patrick Sexton.

Remember to join us tomorrow, May 19th, for the highly anticipated Dr. GPCR Symposium on GPCR Activation and Signaling! If you're interested in presenting a poster, there's still time. Simply submit your information using this form.

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Below is your Classified GPCR News at a glance for May 8th to 14th, 2023.

GPCR Activation and Signaling

• Ligand-induced activation and G protein coupling of prostaglandin F2α receptor.

• Plasma membrane preassociation drives β-arrestin coupling to receptors and activation.

• Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface.

GPCR Binders, Drugs, and more

• In-depth molecular profiling of an intronic GNAO1 mutant as the basis for personalized high-throughput drug screening.

• An allosteric modulator of the adenosine A1 receptor potentiates the antilipolytic effect in rat adipose tissue.

GPCRs in Cardiology, Endocrinology, and Taste

• Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.

GPCRs in Oncology and Immunology

• DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma.

Reviews, GPCRs, and more

• Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey.

• Mechanism of Activation of the Visual Receptor Rhodopsin.

• The application of artificial intelligence to accelerate GPCR drug discovery.

Structural and Molecular Insights into GPCR Function

• New Insights into the Structure and Function of Class B1 GPCRs.

Industry News

• InterAx Biotech to Apply its Leading AI and Cell Signalling Technology to Support Target Validation for a Sosei Heptares GPCR Discovery Program

• Salipro Biotech and DyNAbind Announce Milestone Achievement in Collaboration to Enable DEL for Membrane Proteins

• Professor Andrew Hopkins, Exscientia’s founder and CEO, was elected as a Fellow of the The Royal Society.

• Addex Announces ADX71149 Phase 2 Epilepsy Clinical Study’s Independent Interim Review Committee Recommends Continuing Study

• Addex Therapeutics in the 23rd BioEquity Europe Conference

• Simon Bekker-Jensen and Mette M Rosenkilde received two proof of concept grants from European Research Council (ERC)

• Addex Reports Q1 2023 Financial Results And Provides Corporate Update

• Structure Therapeutics Reports First Quarter 2023 Financial Results and Recent Highlights

• OMass Therapeutics presented at the 23rd BioEquity Conference

• British Patient Capital Invests £10m in next-generation drug development company OMass Therapeutics

• Sosei Heptares 2022 ESG report

• Exscientia Announces Sixth Molecule Created Through Generative AI Platform to Enter Clinical Stage

• X4 Pharmaceuticals Announces Positive Phase 3 Results Showing Mavorixafor Reduced the Rate, Severity, and Duration of Infections vs. Placebo in Participants Diagnosed with WHIM Syndrome

GPCR Events, Meetings, and Webinars

• ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• PEGS Boston (May 15 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• Vice President, Medical Affairs

• Associate Scientist - Technology

• Senior Research Scientist/Principal Scientist- Technology

• Tissue Culture Scientist/Tissue Culture Manager

• Postdoctoral Researcher

• Director - Targeted Oncology

• Senior Scientist - Antibody Engineering

• Scientist—Immuno-Oncology

• Convergent Research - Senior Scientist, Cell-Based Assay Development

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