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568 items found for "GPCR Therapeutics"

  • Chemoattractant receptor signaling in humoral immunity

    < GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity signaling in the context of humoral immunity and discuss the potential of the COMMD3/8 complex as a therapeutic News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

    < GPCR News < GPCRs in Oncology and Immunology A virally encoded GPCR drives glioblastoma through feed-forward News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Dr. GPCR Podcast Audience-Survey | Dr. GPCR Ecosystem

    GPCR Podcast Audience Survey Thanks for listening to the podcast.

  • Ep 79 with Dr. Graeme Milligan

    GPCR Podcast << Back to podcast list Dr. GPCR Board About Dr. main research group centers on the function, structure, and regulation of G protein-coupled receptors (GPCRs Milligan is the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases and Keltic Pharma Therapeutics GPCR Ecosystem Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast

  • Ep 86 with Nicole (Nicki) Perry-Hauser

    GPCR Podcast << Back to podcast list Dr. GPCR Board About Nicole (Nicki) Perry-Hauser I am a postdoctoral research fellow endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor (aGPCR) a basis for understanding aGPCR biology in the nervous system. GPCR Ecosystem Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast

  • Ep 05 with Dr. Terry Hébert

    GPCR Podcast << Back to podcast list Dr. GPCR Board About this episode Dr. Terry Hébert is a Professor within the Department of Pharmacology & Therapeutics at McGill University Much of his work is based on GPCR signaling in the context to cardiovascular diseases. on the web Terry Hébert | Institute of Health Sciences Education Hébert Lab LinkedIn Hébert Lab The GPCR GPCR Ecosystem Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast

  • Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia

    To explore the therapeutic potential of GPR132 signaling, we screened and validated a natural product News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma

    < GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the heterogeneously in glioblastoma (GBM) and is involved in the mesenchymal transition, making it a promising therapeutic News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10

    < GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice

    Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to He received the Canadian Society of Pharmacology and Therapeutics Postdoctoral and Publication awards along with many Young Scientist Awards from the American Society for Pharmacology and Experimental Therapeutics GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

  • Interplay between G protein-coupled receptors and nanotechnology

    nano-GPCRs) may enhance GPCR-related signalling and functions. of biomaterials with GPCRs in therapeutical application." soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in

  • Ep 59 with Dr. Nicola J. Smith

    GPCR Podcast << Back to podcast list Dr. GPCR Board About Dr. Nicola J. Smith Dr. Nicola J Smith is an expert in molecular pharmacology with a track record in exploring GPCR structure-function Smith’s team has made advances in the understanding of how an orphan GPCR exerts its effects both in , named GPCR-CoINPocket. from ‘locked’, inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic targets

  • Ep 83 with Dr. Jean-Philippe Pin

    GPCR VideoCast << Back to VideoCast list Dr. Jean-Philippe Pin About Dr. biosensors, cryo-EM, photoswitchable ligands, and nanobodies as pharmacological tools and potential therapeutic His studies led to new concepts in the GPCR field, such as the activation of cell surface receptors by intracellular proteins; the regulation of GPCRs by both negative and positive allosteric modulators, and the asymmetric functioning of GPCR dimers.

  • Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling

    < GPCR News < GPCRs in Oncology and Immunology Pharmacological inhibition of neuropeptide Y receptors Therefore, these antagonists may aid in the development of novel cancer therapeutics and patient-based Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone

    < GPCR News < GPCRs in Oncology and Immunology Wnt pathway inhibition with the porcupine inhibitor LGK974 serve as a promising therapeutic strategy for FD. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • Ep 84 with Rosie Dawaliby

    GPCR VideoCast << Back to VideoCast list Dr. Rosie Dawaliby About Dr. Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially GPCR I have developed my expertise in the field of pharmacology and biochemistry of GPCR and the crucial role In 2016, I joined a company that specialized in therapeutic candidate discovery targeting GPCR ( Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory diseases

  • Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration

    < GPCR News < GPCRs in Oncology and Immunology Simultaneous activation of CXC chemokine receptor 4 and interplay between CXCR4 and HRH1, and suggest the possibility of the CXCR4-HRH1 heteromer as a potential therapeutic News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions

    an improved understanding of gut microbiota-immune-brain molecular interactions and their potential therapeutic News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Ep 59 with Dr. Nicola J. Smith

    GPCR VideoCast << Back to VideoCast list Dr. Nicola J. Smith About Dr. Nicola J. Smith Dr. Smith’s team has made advances in the understanding of how an orphan GPCR exerts its effects both in , named GPCR-CoINPocket. Her career goal is to leverage this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic targets

  • Ep 56 with Dr. Adriano Marchese

    GPCR Podcast << Back to podcast list Dr. GPCR Board About Dr. Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic GPCR Ecosystem Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast

  • Ep 19 with Dr. Fiona Marshall

    GPCR Podcast << Back to podcast list Dr. GPCR Board About this episode Fiona Marshall got fascinated with GPCRs after attending a lecture on how An expert in GPCR biology, Fiona published the first description of the cloning and structural requirements As a co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery GPCR Ecosystem Listen and subscribe where you get your podcasts << Previous Podcast Episode Next Podcast

  • Contact | Dr. GPCR Ecosystem

    GPCR Ecosystem or want to collaborate? Let's Connect! Address 14 Summer St.

  • Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways

    < GPCR News < GPCRs in Oncology and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine pancreatic adenocarcinoma (PDAC) continues to present a formidable clinical challenge, demanding innovative therapeutic News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis

    < GPCR News < GPCRs in Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions

    < GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor

    < GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in controlling the functions of monocytes and dendritic cells and that targeting GPR141 may be a possible therapeutic Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer

    < GPCR News < GPCRs in Oncology and Immunology Activation of PI3K/Akt pathway by G protein-coupled receptor Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC." News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

  • Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer

    Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer Several of these targets are being developed for potential new therapeutic strategies in ovarian and GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

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