provide an in-depth exploration of key concepts in pharmacology, offering a nuanced understanding of drug interactions

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R activation in gut IELs to modulation of microbiota

Divergence, however, in the amino acid sequences of rodent and human PTH receptors (rat and mouse PTH1Rs are 91% identical to the human PTH1R) can lead to differences in receptor-binding and signaling potencies for such ligands when assessed on rodent vs human PTH1Rs, as shown by cell-based assays in vitro. PTH1R replaces a segment (exon 4) of the murine PTH1R gene so that the human and not the mouse PTH1R functional responses to injected PTH analog peptides that are consistent with a fully functional human

In contrast, less is known about the expression and function of the GLP-1R in human T cells. Here, we provide evidence that activated human T cells express GLP-1R. the present data demonstrate that T cell activation triggers the expression of functional GLP-1R in human Given the high induction of GLP-1R in human iTreg cells, we hypothesize that GLP-1R+ iTreg cells play a key role in the anti-inflammatory effects ascribed to GLP-1R agonists in humans."

interactions Published date October 1, 2023 Abstract "Human-microorganism interactions play a key role a mechanistic insight into the microbe-human interaction. atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions studies for an improved understanding of gut microbiota-immune-brain molecular interactions and their , Human-microbiota interactions , Immune system , Inflammation , Metabolites Source Contribute to the

Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells , TNFAIP8 and TIPE2 were essential for directed migration of human CD4+ T cells. TNFAIP8 interacted with the Gαi subunit of heterotrimeric (α, β, γ) G-proteins whereas TIPE2 bound to Using deletion and site-directed mutagenesis, we established that Gαi interacted with TNFAIP8 through its C terminal amino acids, and that TIPE2 protein interacted with PIP2 and PIP3 through its positively