September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

However, only a small fraction of these metabolites has been identified from the human microbiota thus Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell

Considering that synaptamide is the endogenous metabolite of DHA, we hypothesized that DHA may inhibit

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to from a public human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human molecules across the druggable human GPCRome, a useful framework for integration of microbiome and metabolite protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune system , Inflammation , Metabolites

My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites research, I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. identifying allosteric modulators of host G-protein-coupled receptors (GPCRs) that contribute to cardio-metabolic

My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites research, I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. identifying allosteric modulators of host G-protein-coupled receptors (GPCRs) that contribute to cardio-metabolic