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Dr. GPCR Podcast

Dr. Arthur Christopoulos

About Dr. Sudarshan Rajagopal

Dr. Sudarshan Rajagopal obtained his B.S. in Chemistry from The University of Chicago in 1998. He subsequently enrolled in the Medical Scientist Training Program at The University of Chicago. During his doctoral work in the lab of Prof. Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue crystallography. He was awarded his Ph.D. in 2004 and his MD in 2006. He then joined the Internal Medicine Residency training program at Duke University Medical Center. During his Cardiology fellowship, he trained in the lab of Dr. Robert J. Lefkowitz, where his research focused on biased agonism, with the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased receptors.

After completing his training in clinical cardiology, he started as an Assistant Professor of Medicine at Duke University School of Medicine. The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors and how that contributes to inflammation. The chemokine system is relatively unique in having multiple receptors and multiple ligands that display considerable promiscuity for one another. His group and others have shown that many of these ligands act as biased agonists for the same receptor. His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins. His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center.

Dr. Sudarshan Rajagopal on the web

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