This new study reveals how the conformation of parathyroid hormone (PTH) and the C-terminal helix α5 of Gα regulate the selective coupling of PTH1R to Gs or Gq. Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration, and strength.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️ https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/allosteric-mechanism-in-the-distinctive-coupling-of-gq-and-gs-to-the-parathyroid-hormone-type-1-receptor

#gpcr #drgpcr

What’s one key piece of advice from Ian Chronis in Ep.164 of the Dr.GPCR Podcast?Listen to other scientists’ research—it’s a great way to stay motivated and inspired 🚀 Don’t miss this insightful conversation on GPCRs, pharmacology, and scientific discovery!

✅ https://buff.ly/FTB69y9 

#GPCR #DrGPCR #SciencePodcast #Pharmacology #CancerResearch

Science isn't always about eureka moments—sometimes it's about steady progress.

In our latest Dr. GPCR Podcast episode, Ian Chronis shares his top aha moments, from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling.

✅ https://buff.ly/FTB69y9 

#GPCR #DrGPCR #SciencePodcast #Pharmacology

Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free!

➡️https://buff.ly/e6gAlBv

#gpcr#drgpcr

From aspiring doctor to GPCR scientist! 🔬In this episode, Ian Chronis shares his journey from med school dreams to a PhD in pharmacology, diving into the fascinating world of receptor signaling. Can you guess what’s his favorite GPCR?

✅ Hear his response: Ep 164 with Dr. Ian Chronis 

#SciencePodcast #GPCR #PhDLife #DrGPCR

What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments!

✅ Tune in: https://buff.ly/FTB69y9 

#GPCR #DrGPCR #SciencePodcast

Behind every great discovery is a great question 🚀

Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode.

If you’re passionate about GPCRs and drug discovery, this episode is a must-listen!

✳️Listen at Ep 163 with Dr. Dmitry Veprintsev  

#DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience

In Ep.163 of the Dr. GPCR Podcast, Dr. Dmitry Veprintsev discusses the importance of asking the right GPCR question. It’s not just about learning the techniques; it’s about curiosity! 👀

Do you remember any question that changed your perspective completely? 💡 

✳️Visit https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-  

#DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #GPCRScience

A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor antagonist AH7614 is actually an inverse agonist - suppressing fat cell formation, boosting lipolysis and reducing glucose uptake. Explore how targeting FFA4 could help fight metabolic disorders.

Catch up with the latest research conducted in the Hudson lab in Ep. 161 of the Dr. GPCR Podcast.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function

#GPCR #drGPCR #FFA4 #metabolism #adipocytes

What are your thoughts on β2AR? Listen to Ep.163 of the @DrGPCR Podcast, where @DVeprintsev shares his thoughts and experiences about working with GPCRs, tips on framing your research correctly, and other insightful topics. Don’t miss out!

✳️https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry- 

#GPCRs #SciencePodcast #DrugDiscovery #Biotech #DrGPCR

New Episode Alert! 🎙️

Ep. 163 of the Dr. GPCR Podcast is here! 🚀 This time, we sit down with Dr. Dmitry Veprintsev to discuss the importance of asking the right GPCR questions.

Whether you're a researcher, student, or GPCR enthusiast, this episode is packed with insights that will challenge how you think about your experiments.

✳️Tune in at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-  

#DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #Biotech #GPCRs

How does a superagonist activate M2 muscarinic receptors? New simulations reveal the conformational changes from inactive to active states to highlighting how ligand dynamics drive GPCR activation!  

Catch the full story in the Ecosystem!

https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics

#GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics

🎧 "You will always feel like you know nothing— and that’s completely fine."

In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren shares:🔬 How GPCR spatial organization shapes signaling and drug responses🌍 His interdisciplinary journey from physics to pharmacology💡 Why embracing the unknown is key to scientific breakthroughs

A must-listen for biophysicists, pharmacologists, and drug hunters pushing the boundaries of discovery!

🎙️ Tune in now:Ep 162 with Dr. Gabriele Kockelkoren 

#DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast

A newly engineered biosensor reveals DNAJC13 as a key player in GPCR trafficking, shedding light on its role in DOR downregulation and endosomal regulation.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation 

#gpcr #drgpcr

How does nanoscale GPCR organization shape signaling? 🤔 We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics.

And if you wonder what his favorite GPCR could be, here’s the answer 😉

✅Listen now Ep 162 with Dr. Gabriele Kockelkoren  

#gpcr #drgpcr

🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response.

In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into:

🔬 How GPCR trafficking shapes signaling outcomes

🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs!

🎙️ Listen now https://buff.ly/fYZ1tSq 

#DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast

✅ Tune in today!

A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways 

#gpcr#drgpcr

Do you remember the first time you were left alone in the lab with an experiment? 🤔 Did your experience compare to Dr. Brian Hudson’s? 😄

Tune into this week’s Dr. GPCR Podcast for great stories, GPCR insights, and a fascinating journey that led Dr. Hudson to years of groundbreaking research at the University of Glasgow. Don’t miss out!

✅Listen now https://buff.ly/aEQGUFl

#gpcr #drgpcr

🎯 Crack the code of GPCR ligand development!

In case you haven’t heard, Dr. Terry Kenakin is hosting a 4-week course on GPCR drug development—and registration closes in 3 days! ⚠️

What you’ll learn:✅ Drug absorption, metabolism & clearance✅ PK-PD modeling & therapeutic profiles✅ Early safety assessments & toxicity risks

📌 Limited spots—sign up before March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem 

#GPCR #DrGPCR #Pharma #Biotech #Research

🚨 Exciting Opportunity for Professionals in Drug Development! 🚨

Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs."

🗓 Dates: March 20 - April 10, 2025

⏰ Time: Thursdays, 10:00 AM - 11:30 AM (EST)

This advanced course is essential for anyone working in drug development and focuses on:

The essentials of new drug development

Key pharmacokinetic elements (absorption, distribution, clearance)

Hepatic metabolism and the Cytochrome P450 system

Drug safety and toxicology (including drug-drug interactions)

And much more!

Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to bring therapeutic molecules to life.

🚨 Only 25 spots available — register now!

💡 This is a great opportunity for both academia and industry professionals. Sessions will be live, and you’ll also have 1:1 discussion time with the instructor. Full PDFs of the slides will be available!

🔗 https://buff.ly/lVEcRUc

#GPCR #DrugDevelopment #Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry