Interested in learning more about signaling bias? You’re in the right place! 🙌 Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants 👀

✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias 

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Seeking to gain more knowledge on signaling bias? We’ve got the perfect opportunity for you 🚀 Registrations open until February 14th

⚠️ Last spots available for “The Practical Assessment of Signaling Bias” with Dr. Terry Kenakin

✳️Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias

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Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments!

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor 

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A complete profile = a complete YOU. Highlight your publications, skills, and interests to connect with the right people!

✳️Go to https://www.ecosystem.drgpcr.com/account/my-account and update your profile on the Dr.GPCR.

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Deepen your understanding of signaling bias with Dr. Terry Kenakin's guidance by registering for the latest workshop at Dr.GPCR University 🙌 Register and get hands-on exercises as well as theoretical background for the techniques.✳️Spots are limited—register now! ⬇️

➡️https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias 

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Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free!

Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism and cell growth

➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos 

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New insights into FPR2 signaling! GRK5 drives FPR2 endocytosis, but β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal transduction.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins 

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Check out our #SpotifyWrapped 🚀! In 2024, Dr. GPCR reached listeners worldwide, sparking conversations about GPCRs with top experts. Thank you for tuning in! 📊🎙️

✳️Check out our top episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-148-with-dr-arthur-christopoulos 

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Stay ahead in the GPCR field 💼 Updating your profile ensures you’re ready for the next opportunity.

✳️ Go to https://www.ecosystem.drgpcr.com/account/my-account and let our GPCR-exclusive community know what you’re up to

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This study adds a key piece to the puzzle of adhesion GPCR signaling. Understanding receptor-specific nuances, like the role of NTF cleavage, is crucial for decoding their functional outcomes.

Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership!

➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3 

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In case you haven’t heard, our next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Bias" with Dr. Terry Kenakin. 🙌 Hands-on exercises included!

✳️Only 25 spots available

➡️Enjoy a 25% discount with your Premium Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias 

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Unlock the full potential of the Dr. GPCR platform by updating your profile 🧬 Find like-minded scientists, and colleagues who work on the same topic as you 🙌

✳️Go to https://www.ecosystem.drgpcr.com/account/my-account and update your profile

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Dr. GPCR University is officially back! 🎆 Join Dr. Terry Kenakin for "The Practical Assessment of Signaling Bias" workshop! 🚀

Learn the practical issues with detecting, measuring, and quantifying GPCR ligand-biased signaling.

✳️Early Bird discounts for Premium Members!

➡️Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias 

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Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression.

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a3ar-antagonism-mitigates-metabolic-dysfunction-associated-steatotic-liver-disease-by-exploiting-monocyte-derived-kupffer-cell-necroptosis-and-inflammation-resolution

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What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today

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Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system.

Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! 

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c 

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The Dr. GPCR Podcast is back! After a long break, a new episode will be released today 🎧 Join us in 2025 with a year filled with GPCRs, as we share with specialists about their career paths, the latest breakthroughs, their advice, and inspiring stories.

📅 Ep. 157 drops today January 9th at 10 AM EST. Don’t miss it!

✅ Stay tuned & subscribe at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-157-with-dr.-nagarajan-vaidehi 

Let’s connect the dots! Update your Dr. GPCR profile to make meaningful connections in the global GPCR network 🌐

✳️Visit https://www.ecosystem.drgpcr.com/account/my-account and fill out the boxes with your most updated information.

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New cryo-EM insights reveal how extracellular domains communicate with transmembrane regions in holo-adhesion GPCRs, uncovering mechanisms behind receptor activation.

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➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/conformational-coupling-between-extracellular-and-transmembrane-domains-modulates-holo-adhesion-gpcr-function 

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Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. 

Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox.

➡https://www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/design-of-allosteric-modulators-that-change-gpcr-g-protein-subtype-selectivity 

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