The community is gathering. No agenda. No presentations. Just your people, in one room. Ask any GPCR scientist where the best conversations at a conference happen, and almost no one points to the podium. They point to the hallway. The coffee line. The dinner that ran long because two people realized they'd been circling the same problem from opposite directions. That is the entire idea behind the GPCR Happy Hour. We take away the talks, the slides, and the vendor booths, and we leave the part that actually matters: the people who care most about GPCR science, in one room, with time to talk. We're hosting the GPCR Happy Hour again in Boston On Wednesday, September 30, the Dr. GPCR community gathers for our next Happy Hour, held mid-week during the Discovery on Target meeting. It's a short walk from the sessions, and a very different kind of evening: no agenda, no presentations, no pitches. Just conversation, among scientists who speak the same language from the moment they walk in. It is scientist-only by design, and it is free to every scientist who comes. That is only possible because of our founding co-hosts. This is a community gathering first, and a fundraiser second. Why we keep it small We cap the room on purpose. A smaller gathering is the difference between meeting three people you'll actually remember and shaking forty hands you won't. When the room stays intimate, conversations go deeper, introductions feel natural, and nobody has to shout over a crowd. If you've ever left a networking event wishing you'd had one real conversation instead of twenty short ones, this is the antidote. Made possible by our founding co-hosts The Happy Hour stays free for every scientist because a few companies who genuinely serve the GPCR community step up to make it happen. This edition, we're proud to introduce our Founding Co-Hosts. Axxam Axxam works with drug discovery teams from the very first question, what to go after, all the way through to a real lead. That covers target identification and validation, assay development, and screening, whether a team brings its own compounds or leans on Axxam's. What stood out to us is the science they bring to the hard cases: their own electrophysiology platform, iPSC-derived cell models, optogenetics, and high-content screening. These are the tools GPCR programs reach for when a target just won't cooperate, and it's a big part of why we're glad to have them in the room. Revvity Revvity makes the tools and technologies that help scientists move from an early discovery toward something that reaches patients. In practice that means taking complicated workflows and making them simpler, and helping teams move faster on the science behind new therapeutics, diagnostics, and disease biology. Whether you're piecing together a signaling pathway or designing what comes next, Revvity is the kind of company that gets involved in the science itself, not just the sale. We're grateful to have them co-hosting again, and for helping keep this evening free and open to every scientist. Who should come If you work on GPCRs, this is for you. Pharma, biotech, academia, core facilities, and students are all welcome. Come whether you're presenting at Discovery on Target, attending it, or simply based nearby and looking to spend an evening with the community. The only thing everyone in the room has in common is that they care about this science, and that turns out to be enough. (If you're a CRO or service provider interested in reaching the community, we'd love to talk about co-hosting a future Happy Hour. Reach out any time.) The details When: Wednesday, September 30, from 6:00 PM Where: Pressed Cafe, 105 Huntington Ave, Prudential Center, Boston Who: GPCR scientists across academia and industry Cost: Free for scientists, made possible by our co-hosts Food and drinks: food and one drink ticket included; cash bar available Capacity: Limited to 50, so registration is required Register your spot here Walk in. You already belong. We'll take care of the rest, and we'd love to see you on the 30th.

Boston, MA, September 15, 2026. Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, today announced a strategic partnership with Eurofins Discovery, the drug discovery services side of the same group behind the Eurofins DiscoverX products many in the community already know. For the GPCR community, the partnership means getting to know a comprehensive, end-to-end GPCR drug discovery capability: what it covers, how it works, and the scientists behind it, across every stage of a program. That breadth is the point. Across a program, Eurofins Discovery can: Characterize and rank-order compounds by potency, efficacy, selectivity, and safety Profile biased signaling, allosteric modulation, and species-specific pharmacology Deorphanize receptors and identify new ligands Run functional and binding assays (cAMP, β-arrestin, calcium flux, radioligand binding) and purpose-built panels such as gpcrMAX and orphanMAX And because the services are integrated, a target can move from identification and validation through screening, lead optimization, and regulatory potency testing with a single partner. Backing all of it is more than 30 years of GPCR experience, including over 20 years of integrated drug discovery, a portfolio of more than 2,750 assays, and one of the broadest ranges of GPCR targets in the industry, across therapeutic areas including metabolic disease, oncology and immuno-oncology, immunology, and CNS. "Eurofins Discovery brings real breadth and depth in GPCR pharmacology, and I am glad to feature them to our community," said Dr. Yamina Berchiche, Founder and CEO of Dr. GPCR. "Whatever stage a team is at, the services and the expertise are there to move a program forward with confidence." "Dr. GPCR has built a trusted home for the global GPCR community," said Lakshmi Anantharaman, Director of Screening, LeadHunter Services, Eurofins Discovery. "We look forward to sharing our science, our services, and our team's expertise with researchers advancing GPCR-targeted therapeutics." Dr. GPCR and Eurofins Discovery join forces and aim to accelerate GPCR-targeted drug discovery by pairing comprehensive, end-to-end services with an engaged global community of GPCR researchers, and the scientific context that helps teams design better experiments and interpret their data with confidence. Over the coming year, the community will get to know these services, and the scientists behind them, more closely. About Dr. GPCR Dr. GPCR is a nonprofit organization connecting the global GPCR community through training, curated news, expert-led courses, and networking. With over 189 podcast episodes, live and on-demand educational programs, and a growing partner ecosystem, Dr. GPCR empowers scientists and organizations advancing GPCR biology and GPCR-targeted drug discovery. To learn more about Dr. GPCR's educational programs and global GPCR community, visit https://www.ecosystem.drgpcr.com/gpcr-university About Eurofins Discovery Eurofins Discovery is a global drug discovery services provider offering comprehensive, end-to-end GPCR solutions. With more than 30 years of GPCR experience, including over 20 years of integrated drug discovery, a portfolio of more than 2,750 assays, and one of the broadest ranges of GPCR targets in the industry, Eurofins Discovery supports researchers from target validation through candidate advancement, spanning screening, functional and binding pharmacology, custom assay development, and integrated programs. To explore Eurofins Discovery's GPCR services and resources, visit: https://www.ecosystem.drgpcr.com/eurofins-discovery-gpcr-services

Join Dr. GPCR at Discovery on Target 2026 in Boston, where GPCR science runs right through the heart of modern drug hunting. If you work in drug discovery or biotech, Boston in the fall is where the conversation happens. Discovery on Target returns September 28 to October 1, 2026, and this year GPCR science is woven into the broader Lead Generation Strategies program, sitting alongside covalent chemistry, DNA-encoded libraries, biophysics, and direct-to-biology. For us, that is a feature, not a footnote. GPCRs do not live in isolation, and neither do the people working on them. Seeing GPCR programs share a room with the newest hit-finding and lead-generation approaches is exactly how the field moves forward. Our founder, Yamina Berchiche, PhD, is honored to be chairing the Targeting GPCRs session on Wednesday, September 30. In the run-up to the meeting, she sat down with several of the scientists presenting and teaching this year to hear what they are bringing to Boston. Speaker Spotlight Ahead of the meeting, we sat down with four of the scientists presenting and teaching in the GPCR track this year. Here are our conversations. Evan O'Brien, PhD, Johns Hopkins University Dr. O'Brien runs a lab at Johns Hopkins that blends cryo-electron microscopy with protein dynamics to build something closer to a movie of GPCR allostery than a single snapshot. His talk digs into the molecular basis of partial agonism at the mu opioid receptor, using mitragynine pseudoindoxyl and a newly identified allosteric pocket to tune signaling like a rheostat. In a result the field will enjoy, his team solved the same molecule bound in both the active and inactive states of the receptor, and the weak partial agonist still delivered meaningful pain relief in a mouse model. A great example of why what happens in the animal matters as much as what happens in the in vitro assay. Hailong Zhang, PhD, Shanghai Yogar Therapeutics Dr. Zhang is a structural biologist with more than two decades in small molecule research across oncology and metabolic disease. At Discovery on Target he presents YJ-015, a G protein biased APJ agonist developed as an adjuvant to GLP-1 therapy. The idea is elegant: GLP-1 agonists drive rapid weight loss but can take muscle along with the fat, and YJ-015 is designed to preserve muscle while the weight comes off. It is a timely look at how receptor pharmacology can sharpen one of the most talked-about therapeutic areas in the field. Kris Borzilleri, Pfizer A familiar face from last year, Kris Borzilleri is a longtime discovery scientist at Pfizer who moved from soluble proteins into the membrane protein world, bringing a deep biophysics toolkit with her. At Discovery on Target she is giving a talk on an NMR fragment screen against an orphan GPCR, describing how her team navigated hit follow-up to drive down compound potency. She is also co-teaching a short course on biophysical methods for GPCRs, covering protein NMR, SPR, and whole-cell SPR microscopy. Catch her on both the podium and in the classroom. Dr. Terry Kenakin, UNC and Head Instructor at Terry's Corner Dr. Kenakin is teaching a brand-new full-day short course in Boston on Monday, September 28: "The End Game: From Lead Optimization to Drug Candidate Selection." Six hours of instruction centered on the part of discovery where much of the attrition happens, once you actually have a compound in hand. Expect deep, practical treatment of affinity and efficacy, allosteric protein function, early safety, ADME, kinetics, and real case studies of compounds that looked promising and failed in the clinic, with a clear eye on why. As Dr. Kenakin puts it, the goal is to translate moving biological readouts into hard chemical terms that hold up and predict what a molecule will do in people. Why Dr. GPCR Is in This Conversation At Dr. GPCR, our mission is simple: connect the GPCR community, share knowledge, and accelerate innovation. Chairing the GPCR session at Discovery on Target is an extension of what we do every day, spotlighting strong science across academia and industry and bringing the people behind it together. We are a nonprofit, and we have spent six years building a trusted, science-first space for this community. Stepping into the GPCR track at Discovery on Target is part of that work. Inside the GPCR Track This Year The GPCR content is concentrated on Wednesday, September 30, and it spans an unusually wide slice of the field: Antifibrotic and anti-inflammatory targets, including GPR68 Biased ligand discovery and orphan receptors such as GPR75 Designer partial agonism at the mu opioid receptor Small molecule approaches to obesity through GIPR Muscle-sparing strategies for GLP-1-driven weight loss through APJ Structural biology of the opioid receptors using single molecule FRET and cryo-EM Fragment-based discovery for orphan GPCRs Membrane mimetics and how the lipid environment shapes receptor behavior There is also a morning roundtable on modern GPCR-targeted drug discovery, tackling which hit-finding strategies are actually delivering tractable GPCR leads, where AI and machine learning genuinely change the workflow, and which functional readouts teams trust enough to make go or no-go decisions. Keep Learning with Terry's Corner If you cannot get enough of Dr. Kenakin's teaching, Terry's Corner is our room where he breaks down receptor pharmacology, functional selectivity, and ligand bias in ways you can apply directly to your work. You can also sign up for the free weekly Kenakin brief delivered to your inbox at https://www.ecosystem.drgpcr.com/terry-corner#signuptc. We have GPCR-focused courses coming this fall as well, so stay tuned. Join Us in Boston Discovery on Target, Boston, MA. September 28 to October 1, 2026 Track: Lead Generation Strategies, with GPCR sessions on Wednesday, September 30 Registration and full agenda Use code GPCR26200 for $200 off the current registration rate as part of our collaboration with Discovery on Target. Let's connect, let's debate, and let's keep moving GPCR drug discovery forward, together.

Advanced GPCR webinars for pharmacologists and biotech scientists. Live Q&A. Deep mechanistic insight. Reserve your seat. University / Free & Live Webinar Live GPCR Webinars with the World's Leading Experts. Deep-dive sessions focused on real pharmacology, real drug discovery challenges, and real translational insight. Live Q&A with the scientists shaping the field. Live for those who can be there. On demand for everyone else. 👉 Sign Up for Notifications Get the live link before each session Strategic Partners Webinars Upcoming Live & On Demand Webinars Tuning GPCR System Sensitivity: Revealing True Drug Activity Through Functional Volume Control Speaker: Dr. Terry Kenakin | Terry's Pharmacology Corner What you'll learn during the session: How functional system sensitivity for receptor expression becomes a tool for determining the properties of a molecule Why testing agonists in low sensitivity systems separates affinity and efficacy and enables prediction of agonism in other systems How testing antagonists in high sensitivity systems detects low levels of efficacy and, through constitutive activity, inverse agonism How volume control reveals essential properties of allosteric modulators, including PAM-agonism and changes in efficacy 📅 September 24, 2026 at 11:00:00 AM Details Recombinant Antibodies for GPCRs: A Challenge to the Community Speakers Dr. Alexander Ball, MD Dr. Alexander Ball of GeneTex joins Dr. GPCR to walk through what the company is doing about it, and the challenge it comes with: A high-throughput recombinant antibody platform built for specificity at scale Prioritized validation: CRISPR KO/KD, endogenous expression, cell fractionation, comparable antibodies, application-specific testing VirDTM-GPCR arrays for cross-reactivity screening when feasible More than 300 recombinant mAbs against almost 200 human GPCRs, and growing Free samples for GPCR researchers who will test the antibodies in their own labs and give structured feedback 📅 June 25, 2026 at 11:00:00 AM Details Receptor Signaling Bias: A Valuable and Accessible Property of New Drug Candidates Speaker Dr. Terry Kenakin - UNC Chappel Hill | Terry's Pharmacology Corner Topics Covered The biological basis of receptor signaling bias and ligand-dependent conformations How to design functional assay panels that quantify bias rather than infer it Interpretation pitfalls and what assay system choice does to bias estimates Translating pathway-level data into lead selection and optimization decisions Why potency alone is not enough for candidate-level decisions 📅 May 28, 2026 at 11:00:00 AM Details 1 2 1 ... 1 2 ... 2 1,400+ Scientists in the Ecosystem 30+ Countries Represented 60–90 Scientists per Live Session Free Always. No Paywall. No Catch. Use It Tomorrow Practical takeaways, every session. Walk away with something you can apply in your next experiment, assay, or project decision. Together in the Room Scientists from around the world, in the same conversation. The chat, the Q&A, the shared curiosity — the community thinking together in real time. Free and Generous No paywall. No catch. The ecosystem gives this away because GPCR scientists deserve access to high-quality science. Sign up, show up, bring your questions. Direct Access Ask an expert a live question and get a real answer. That direct access doesn't exist at conferences — it exists here. No Borders Live for those who can be there. On demand for everyone else. The GPCR community doesn't stop at borders — and neither do we. Stay Ahead Learn about methods, tools, and approaches before they become widely known. Be ahead of colleagues who aren't in the ecosystem. What Makes These Webinars Different? Not a lecture. A scientific exchange. Built for the GPCR community, by the GPCR community. Every session is designed to move your science forward. First Dr. GPCR event? Welcome. This is what the community looks like — scientists from around the world, thinking through discovery challenges together. There's no paywall, no catch. Just real science and real exchange. If this is your first session, there's a lot more where this came from. Want to Go Deeper? This Is Just the Beginning If a free webinar is this good, imagine what the full ecosystem looks like. Dr. GPCR University brings you premium Masterclass sessions, 200+ recordings, weekly curated news, and a global community of GPCR scientists — all in one place. Webinar → Weekly News → 14-Day Trial → University Premium 👉 Sign Up for Notifications These sessions are part of a larger mission: building the most trusted home for GPCR scientists worldwide. Frequently Asked Questions Questions about the webinars What are GPCR webinars? GPCR webinars are free, live online scientific sessions focused on G protein-coupled receptor biology, pharmacology, signaling, and drug discovery. Each session explores mechanistic models, translational challenges, and real-world therapeutic implications through presentations and live Q&A. They're designed for scientists who want deep, data-driven discussion rather than surface-level overviews. Who should attend? Any scientist working with GPCRs — pharmacologists, medicinal chemists, cell biologists, translational researchers, discovery teams, postdocs, PIs, and industry scientists. Whether you're deep in receptor biology or evaluating assay tools, these sessions are built for you. Are the webinars free? Yes. Always. No paywall, no catch. Sign up with a free registration and you'll receive the live link before each session. Recordings are also freely available on demand afterward. Are the webinars live or pre-recorded? All webinars are live events with real-time Q&A — that's the point. After the live session, the full recording becomes available on demand so scientists in every time zone can access the same content and depth. How are these different from conference talks or academic seminars? The Q&A is the core, not an afterthought. These sessions are designed for interaction — scientists asking direct questions and getting real answers. There's no travel required, no registration fee, and you're in a room with researchers from dozens of countries who share your focus on GPCRs. What topics are typically covered? GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design, drug discovery workflows, translational challenges, and the science behind emerging tools and methods. Every session is grounded in receptor biology with a focus on what's practical and applicable. Do I need prior knowledge of GPCR pharmacology? A working understanding of GPCR biology helps you get the most from each session. That said, the presenters are skilled at making complex science accessible, and the Q&A often covers foundational questions alongside advanced discussion. Where can I find more advanced GPCR training? If you want to go deeper, Dr. GPCR University offers premium Masterclass sessions with frontier science, unresolved questions, and extended scientific exchange — exclusively with independent scientists. The webinars are the open door; Masterclass is the room you earn access to. You can explore University with a 14-day trial. Be in the Room When the Science Moves Forward Sign up to get notifications about upcoming webinars. Bring your questions. 👉 Sign Up for Notifications

Dr. GPCR Podcast - The Voice of the Community Whether you’re a scientist, student, or just curious, you’ll hear about discoveries, career stories, and the latest GPCR news. Jump in and get inspired! Strategic Partners Latest Podcast Episodes Select by Guest Name 2026-09-09 2026-05-13 2026-03-18 2026-02-04 2026-06-10 2026-04-29 2026-03-04 2025-12-17 2026-05-27 2026-04-01 2026-02-18 2025-12-03 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 ... 16 Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Listen and subscribe where you get your podcasts

Join the scientific exchange in the room with the scientist, not watching from the audience. Access 200+ expert sessions at Dr. GPCR University. University / Live Masterclass Sessions In the room with the scientist, not watching from the audience. Live scientific exchanges with leading GPCR experts. Interactive, question-driven, frontier science. This isn't a lecture — it's a conversation with the people shaping GPCR discovery. Masterclass is included inDr. GPCR University Try it for 14 days Upcoming live sessions Your next Live Masterclass Session is waiting Each session focuses on a specific pharmacology or GPCR discovery topic, led by a recognized expert. Live Q&A means your questions get real answers. Introduction to GLP-1 pharmacology Dr. Marsha Pierce | Midewestern University October 29, 2026 Translational Pharmacology & Disease Models Details Conformational Biosensors for GPCR Activation Dr. Katarina Nemec and Dr. Romy Thomas December 10, 2026 Assay Development Details What makes this different? Not a lecture. Not a webinar. A scientific exchange. The Masterclass was created because the most valuable insights in GPCR science aren't captured in papers or conference talks. Scientist-to-scientist discussion Extended Q&A allows deeper exploration than typical presentations. You're engaging directly with the expert — not submitting a question to a moderator. Beyond conference time limits Topics are explored in greater depth than standard conference talks allow. Sessions focus on scientific reasoning, data interpretation, and real discovery problems. Focused audience of specialists Sessions bring together GPCR researchers, pharmacologists, and discovery scientists. The conversation stays at the right level because everyone in the room speaks the same scientific language. Every session recorded Can't make it live? Every Masterclass is recorded and available on demand in the library. Revisit the science anytime — over 200 sessions and growing. On-demand library 200+ expert sessions, available anytime Full recordings of every Masterclass session. Revisit the science at your pace — filter by category, level, or instructor. Explore all Recorded Masterclasses → The scientists Learn directly from world leaders in GPCR research Adriano Marchese Dmitry Veprintsev Marsha Pierce Sudarshan Rajagopal Andrew Tobin Jakob Höppner Matteo Pavan Terry Hébert Bryan Roth Katarina Nemec Romy Thomas Terry Kenakin Davide Calebiro Kenneth Jacobson Samuel Hoare Yamina Berchiche What scientists say? From the people in the room I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. GPCR researcher Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field GPCR researcher The content had enough depth to satisfy the hunger for theory while being full of practical knowledge GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology GPCR researcher Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him GPCR researcher Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. GPCR researcher The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work GPCR researcher About the GPCR Masterclass What is a GPCR Masterclass? The GPCR Masterclass is a live scientific discussion with a leading expert in GPCR pharmacology, receptor biology, or drug discovery. Sessions focus on research questions, experimental interpretation, and emerging challenges in GPCR science. Are the sessions live or recorded? Masterclass sessions are conducted live with an invited expert. After the event, recordings are added to the Masterclass course library, where Premium Members can access them on demand. Who should join? The Masterclass is designed for GPCR researchers, pharmacologists, and drug discovery scientists working in academia, biotech, and pharmaceutical research. Can I watch sessions later if I miss the live event? Yes. All sessions are recorded and available in the Masterclass course library for Premium Members. Can I watch sessions later if I miss the live event? Yes. All sessions are recorded and available in the Masterclass course library for Premium Members. How do I fit this in my schedule? You can attend the live discussion or watch the recording later. The Masterclass library allows members to revisit sessions at any time. What makes the Masterclass different from reading papers or textbooks? The Masterclass focuses on scientific interpretation and discussion. Experts explain how they think about pharmacological data, experimental design, and discovery challenges—insight that is rarely captured in publications. What happens during the live discussion? Each session begins with a focused presentation from the guest expert, followed by moderated discussion and questions from participants. The format allows deeper exploration of pharmacology concepts than typical conference presentations. Masterclass is included in Dr. GPCR University Live sessions, 200+ on-demand recordings, plus premium intelligence, jobs, events, and a community of GPCR scientists — all in one place. See what it feels like for 14 days. Try University for 14 days — $50 Your professional home in GPCR science. $499/year after trial.