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- Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists with Dr. Maria Majellaro from Celtarys | Dr. GPCR Ecosystem
GPCR and Celtarys, built on a shared commitment to empowering the GPCR research community. GPCR. GPCR ecosystem. GPCR and Celtarys. GPCR ecosystem , GPCR drug discovery , fluorescent ligands , GPCR scientist network , custom ligand development
- Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out the latest GPCR news in the Ecosystem today! #drgpcr Published on January 14, 2025 Category GPCR Weekly News Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out the latest GPCR news in the Ecosystem today!
- ama session sept 18 post 1 | Dr. GPCR Ecosystem
Join Terry’s Corner AMA to master GPCR signaling, allosteric modulation, and kinetic strategy in drug In this AMA session, you’ll learn how to: Decode GPCR signaling complexity using functional assay strategies GPCR Ecosystem ✳️ BONUS — Live AMA Session: Get direct, unfiltered access to Terry. #GPCR #DrGPCR #Pharmacology #DrugDiscovery #Biotech #AllostericModulation #Kinetics #AssayDevelopment
- Irfan Dhanidina, Dr. Kathleen Caron and Dr. Lauren Slosky | Dr. GPCR Ecosystem
GPCR Podcast Strategic Partners Irfan Dhanidina, Dr. Kathleen Caron and Dr. With respect to GPCRs, I'm particularly interested in peptide/small protein receptors and the mechanisms GPCR About Dr. Kathleen Caron " "Kathleen M. Caron, Ph.D. is the Frederik L. GPCR About Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review.
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to : RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by
- GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins control signal transduction beyond adenylyl cyclase suppression? New research sheds light on these pathways! ✨ Want to learn more? Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! | Dr. GPCR Ecosystem
Home → Flash News → GPCRs regulate key biological processes, but how exactly do inhibitory Gαi proteins Did you know that we work hard to bring you the most recent GPCR News, weekly? Published on October 22, 2024 Category GPCR Weekly News GPCRs regulate key biological processes, but Did you know that we work hard to bring you the most recent GPCR News, weekly? receptor-activation-and-signaling/germline-mutations-in-a-g-protein-identify-signaling-cross-talk-in-t-cells #GPCR
- Did you know that A2B adenosine receptor-triggered calcium mobilization varies by cell type? A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling, revealing a more complex regulation than previously thought. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity Published on March 10, 2025 Category GPCR Weekly News Did you know that GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr
- Coffee Break with pastries announcement of the aGEM award | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- Mexico City Nocturnal Tour, Food and drinks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr | Dr. GPCR Ecosystem
✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Published on January 15, 2025 Category Dr. GPCR Profiles What can an updated profile do for you? ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Previous Next Recent Articles
- New insights into FPR2 signaling! GRK5 drives FPR2 endocytosis, but β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal transduction. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr #drgpcr Published on January 30, 2025 Category GPCR Weekly News New insights into FPR2 signaling! Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr
- Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://buff.ly/e6gAlBv #gpcr#drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! ➡️https://buff.ly/e6gAlBv #gpcr#drgpcr Published on April 21, 2025 Category GPCR Weekly News Check out Check out the latest GPCR news in the Ecosystem today! ➡️ https:// buff.ly/e6gAlBv #gpcr#drgpcr Previous Next Recent Articles
- Content Guidelines | Dr. GPCR Ecosystem
GPCR Ecosystem website. Get the information you need to create engaging and impactful content. GPCR, Corp, LLC (“Dr. GPCR”) provides its Service to you through our websites referred to as Dr. GPCR, Ecosystem.DrGPCR.com, DrGPCR.com. Please note that Ecosystem.DrGPCR.com is specializes in GPCR and related subjects. Keep in mind that online harassment is also illegal in many places and can have serious offline consequences
- ep 169 with sokhom pin some 2 | Dr. GPCR Ecosystem
GPCR Podcast Build the team you always wished you had. At Alkermes, Sokhom S. It was leadership. ✳️ Watch Ep. 169: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin
- A Brief History of allosteric modulation with Dr. Arthur Christopoulos | Dr. GPCR Ecosystem
GPCR Podcast Strategic Partners A Brief History of allosteric modulation with Dr. His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and They also discussed their upcoming trips to the GPCR Colloquium in California and current research in GPCR Podcast? Leave a Review. Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research
- Weekly News October 16 | Dr. GPCR Ecosystem
Home → Flash News → Weekly News October 16 Published on October 16, 2025 Category GPCR Weekly News Enzymes #DrGPCR #GPCR Previous Next Recent Articles
- Some biotech stories start in the lab. Celtarys started with a thesis project, a new chemical strategy, and a vision to make fluorescence available for drug discovery. Now, they’re growing fast and partnering with Dr. GPCR to connect with the researchers who need them most. ✳️ Learn more about the partnership: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRcommunity #ScienceCollaboration #FluorescentLigands #BiotechStartup | Dr. GPCR Ecosystem
GPCR to connect with the researchers who need them most. ✳️ Learn more about the partnership: https:/ /www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRcommunity #ScienceCollaboration #FluorescentLigands GPCR to connect with the researchers who need them most. ✳️ Learn more about the partnership: https:/ /www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRcommunity #ScienceCollaboration #FluorescentLigands
- 10 GPCR pharmacology lessons. Zero fluff. Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with: • The role of pharmacology in discovery strategy • Black & Leff’s operational model—finally made practical • Binding curves, orthosteric vs allosteric function, and real vs apparent affinity • Molecular dynamics and how they guide ligand design • Why Terry built this—and how it sharpens your next move 📅 Learn anytime. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbinding | Dr. GPCR Ecosystem
Home → Flash News → 10 GPCR pharmacology lessons. Zero fluff. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience TerrysCorner #GPCRpharmacology #ligandbinding Published on June 30, 2025 Category Terry's Corner 10 GPCR New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience
- Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRdrugDiscovery #GPCRecosystem #CustomLigands | Dr. GPCR Ecosystem
GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem
- C-Principles of Pharmacology in Drug Discovery 1 | Dr. GPCR Ecosystem
still are the most prolific and fertile therapeutic drug targets; this course describes the essential The course will focus on the methods used to quantify GPCR ligand activity (agonists, antagonists, modulators Participants who complete the course will get an online certification signed by the professor and the What others are saying about the courses Dr. Hoare is very experienced in the field. Thoroughly enjoyed learning from him Anonymous Thank you for bringing this course with Dr. Kenakin.
- irreversible drugs post 1 | Dr. GPCR Ecosystem
GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #DrugDiscovery #MedicinalChemistry #PKPD #ReceptorKinetics
- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
GPCR Podcast Forget one receptor at a time. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped GPCR News 5 days ago
- Content and Conduct Policy | Dr. GPCR Ecosystem
GPCR Ecosystem and promote a positive online community. Content and Conduct Policy Dr. GPCR, Corp, LLC (“Dr. GPCR”) provides its Service to you through our websites referred to as Dr. GPCR, Ecosystem.DrGPCR.com, DrGPCR.com. Please note that Ecosystem.DrGPCR.com is specializes in GPCR and related subjects. Keep in mind that online harassment is also illegal in many places and can have serious offline consequences
- 🎧 "You will always feel like you know nothing— and that’s completely fine." In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren shares: 🔬 How GPCR spatial organization shapes signaling and drug responses 🌍 His interdisciplinary journey from physics to pharmacology 💡 Why embracing the unknown is key to scientific breakthroughs A must-listen for biophysicists, pharmacologists, and drug hunters pushing the boundaries of discovery! 🎙️ Tune in now:Ep 162 with Dr. Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast | Dr. GPCR Ecosystem
Gabriele Kockelkoren shares: 🔬 How GPCR spatial organization shapes signaling and drug responses 🌍 Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast Published GPCR Podcast 🎧 "You will always feel like you know nothing— and that’s completely fine." Gabriele Kockelkoren shares:🔬 How GPCR spatial organization shapes signaling and drug responses🌍 His Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast Previous
- Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr Published on February 13, 2025 Category GPCR Weekly News Did you know that GPR20, a potential Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Exploring the combination of molecular simulation, pharmacological assays, and NMR to reveal the molecular mechanism of biased activation at the vasopressin V2 receptor. Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! | Dr. GPCR Ecosystem
Did you know that we work hard to bring you the most recent GPCR News, weekly? Published on December 10, 2024 Category GPCR Weekly News Exploring the combination of molecular simulation Did you know that we work hard to bring you the most recent GPCR News, weekly? 2B-chemokine-ligands-show-g-protein-bias-over-%CE%B2-arrestin-recruitment-and-receptor-internalization-in-cxcr1-signalling #gpcr
- insights into g protein coupling preference from cryo em structures of gq bound PTH1R | Dr. GPCR Ecosystem
protein coupling preference from cryo em structures of gq bound PTH1R Published on July 14, 2025 Category GPCR Strategic implications for biased agonist design A critical advance for anyone working on class B1 GPCRs utm_content=buffer3b1fa&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer #DrGPCR #GPCR #PTH1R
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Home → Flash News → How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias barcodes influence β-arrestin binding to GPCRs? Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #
- New strategic partnership alert! 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. 🧪 “We don’t just deliver compounds. We solve assay problems.” – Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment | Dr. GPCR Ecosystem
🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast GPCR Podcast New strategic partnership alert! 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast
