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Until recently, itch pathophysiology was poorly understood and treatments were poorly effective in relieving

desensitized PAR2 have been misconceived as antagonists, and this has impeded a better understanding of the pathophysiological uniquely modulates PAR2-mediated cellular signaling and is a useful pharmacological tool for studying the pathophysiological

Although GPCRs are implicated in the pathophysiology of Alzheimer's disease (AD), biased GPCR signaling Here, we generated a G protein-biased GPR3 mouse model to investigate the physiological and pathophysiological

receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological

models, and as he puts it has now he’s "gone full circle" back to studying GPCRs important in human pathophysiology

and receptor crosstalk, and applying these mechanisms for distinct GPCRs in diverse physiological and pathophysiological